Human Gene KCNK16 (ENST00000373229.9) from GENCODE V44
Description: Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 2, mRNA. (from RefSeq NM_032115) RefSeq Summary (NM_032115): The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]. Gencode Transcript: ENST00000373229.9 Gencode Gene: ENSG00000095981.11 Transcript (Including UTRs) Position: hg38 chr6:39,314,698-39,322,554 Size: 7,857 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr6:39,315,002-39,322,540 Size: 7,539 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96T55
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005244 voltage-gated ion channel activity GO:0005267 potassium channel activity GO:0005515 protein binding GO:0022841 potassium ion leak channel activity
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0030322 stabilization of membrane potential GO:0034765 regulation of ion transmembrane transport GO:0071805 potassium ion transmembrane transport