Human Gene DAAM2 (ENST00000274867.9) from GENCODE V44
Description: Homo sapiens dishevelled associated activator of morphogenesis 2 (DAAM2), transcript variant 1, mRNA. (from RefSeq NM_001201427)
Gencode Transcript: ENST00000274867.9
Gencode Gene: ENSG00000146122.17
Transcript (Including UTRs)
Position: hg38 chr6:39,792,376-39,904,869 Size: 112,494 Total Exon Count: 25 Strand: +
Coding Region
Position: hg38 chr6:39,856,303-39,902,037 Size: 45,735 Coding Exon Count: 24
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: DAAM2_HUMAN
DESCRIPTION: RecName: Full=Disheveled-associated activator of morphogenesis 2;
TISSUE SPECIFICITY: Expressed in most tissues examined.DOMAIN: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).SIMILARITY: Belongs to the formin homology family.SIMILARITY: Contains 1 DAD (diaphanous autoregulatory) domain.SIMILARITY: Contains 1 FH1 (formin homology 1) domain.SIMILARITY: Contains 1 FH2 (formin homology 2) domain.SIMILARITY: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.SEQUENCE CAUTION: Sequence=BAA20835.2; Type=Erroneous initiation;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR003104 - Actin-bd_FH2/DRF_autoreg
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR014767 - Diaphanous_autoregulatory
IPR010472 - Drf_FH3
IPR010473 - Drf_GTPase-bd
IPR015425 - FH2_actin-bd
IPR014768 - GTPase-bd/formin_homology_3
Pfam Domains: PF06367 - Diaphanous FH3 Domain
PF06371 - Diaphanous GTPase-binding Domain
PF02181 - Formin Homology 2 Domain
ModBase Predicted Comparative 3D Structure on Q86T65
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003779 actin binding
GO:0017048 Rho GTPase binding
Biological Process: GO:0007368 determination of left/right symmetry
GO:0016043 cellular component organization
GO:0016055 Wnt signaling pathway
GO:0021516 dorsal spinal cord development
GO:0030036 actin cytoskeleton organization
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000050 regulation of non-canonical Wnt signaling pathway
Cellular Component: GO:0070062 extracellular exosome
Descriptions from all associated GenBank mRNAs
AK091749 - Homo sapiens cDNA FLJ34430 fis, clone HLUNG2000846.AX747160 - Sequence 685 from Patent EP1308459.AK310941 - Homo sapiens cDNA, FLJ17983.AB002379 - Homo sapiens KIAA0381 mRNA for KIAA0381 protein.BC047575 - Homo sapiens dishevelled associated activator of morphogenesis 2, mRNA (cDNA clone IMAGE:4814116), with apparent retained intron.AL833083 - Homo sapiens mRNA; cDNA DKFZp451J0719 (from clone DKFZp451J0719); complete cds.BC128388 - Homo sapiens dishevelled associated activator of morphogenesis 2, mRNA (cDNA clone IMAGE:40124624), containing frame-shift errors.BC078153 - Homo sapiens dishevelled associated activator of morphogenesis 2, mRNA (cDNA clone IMAGE:6061573), complete cds.CU687318 - Synthetic construct Homo sapiens gateway clone IMAGE:100022885 5' read DAAM2 mRNA.KJ902346 - Synthetic construct Homo sapiens clone ccsbBroadEn_11740 DAAM2 gene, encodes complete protein.EU832000 - Synthetic construct Homo sapiens clone HAIB:100067029; DKFZo004A0624 dishevelled associated activator of morphogenesis 2 protein (DAAM2) gene, encodes complete protein.EU831906 - Synthetic construct Homo sapiens clone HAIB:100066935; DKFZo008A0623 dishevelled associated activator of morphogenesis 2 protein (DAAM2) gene, encodes complete protein.AB384471 - Synthetic construct DNA, clone: pF1KA0381, Homo sapiens DAAM2 gene for disheveled-associated activator of morphogenesis 2, complete cds, without stop codon, in Flexi system.AK310111 - Homo sapiens cDNA, FLJ17153.BX647839 - Homo sapiens mRNA; cDNA DKFZp451D2311 (from clone DKFZp451D2311).BC014275 - Homo sapiens dishevelled associated activator of morphogenesis 2, mRNA (cDNA clone IMAGE:3831210), partial cds.JD092281 - Sequence 73305 from Patent EP1572962.JD373273 - Sequence 354297 from Patent EP1572962.JD472010 - Sequence 453034 from Patent EP1572962.JD283948 - Sequence 264972 from Patent EP1572962.JD233203 - Sequence 214227 from Patent EP1572962.BC047555 - Homo sapiens dishevelled associated activator of morphogenesis 2, mRNA (cDNA clone IMAGE:5303137).JD553022 - Sequence 534046 from Patent EP1572962.JD244770 - Sequence 225794 from Patent EP1572962.JD341902 - Sequence 322926 from Patent EP1572962.JD200487 - Sequence 181511 from Patent EP1572962.JD455610 - Sequence 436634 from Patent EP1572962.JD272773 - Sequence 253797 from Patent EP1572962.JD507986 - Sequence 489010 from Patent EP1572962.JD221608 - Sequence 202632 from Patent EP1572962.JD469458 - Sequence 450482 from Patent EP1572962.JD091768 - Sequence 72792 from Patent EP1572962.JD252819 - Sequence 233843 from Patent EP1572962.JD254390 - Sequence 235414 from Patent EP1572962.JD429009 - Sequence 410033 from Patent EP1572962.JD510719 - Sequence 491743 from Patent EP1572962.JD131496 - Sequence 112520 from Patent EP1572962.JD149855 - Sequence 130879 from Patent EP1572962.JD148184 - Sequence 129208 from Patent EP1572962.JD124157 - Sequence 105181 from Patent EP1572962.JD562278 - Sequence 543302 from Patent EP1572962.JD252083 - Sequence 233107 from Patent EP1572962.JD186007 - Sequence 167031 from Patent EP1572962.JD098197 - Sequence 79221 from Patent EP1572962.JD053064 - Sequence 34088 from Patent EP1572962.JD113025 - Sequence 94049 from Patent EP1572962.JD467152 - Sequence 448176 from Patent EP1572962.JD548038 - Sequence 529062 from Patent EP1572962.JD287737 - Sequence 268761 from Patent EP1572962.JD537716 - Sequence 518740 from Patent EP1572962.JD530524 - Sequence 511548 from Patent EP1572962.JD527261 - Sequence 508285 from Patent EP1572962.JD386174 - Sequence 367198 from Patent EP1572962.JD330267 - Sequence 311291 from Patent EP1572962.JD553581 - Sequence 534605 from Patent EP1572962.JD130460 - Sequence 111484 from Patent EP1572962.JD145183 - Sequence 126207 from Patent EP1572962.JD422522 - Sequence 403546 from Patent EP1572962.JD195636 - Sequence 176660 from Patent EP1572962.JD101582 - Sequence 82606 from Patent EP1572962.JD151204 - Sequence 132228 from Patent EP1572962.JD450416 - Sequence 431440 from Patent EP1572962.JD361471 - Sequence 342495 from Patent EP1572962.JD071087 - Sequence 52111 from Patent EP1572962.JD455985 - Sequence 437009 from Patent EP1572962.JD374138 - Sequence 355162 from Patent EP1572962.JD530480 - Sequence 511504 from Patent EP1572962.JD381539 - Sequence 362563 from Patent EP1572962.JD234722 - Sequence 215746 from Patent EP1572962.JD539365 - Sequence 520389 from Patent EP1572962.JD368705 - Sequence 349729 from Patent EP1572962.JD147350 - Sequence 128374 from Patent EP1572962.JD324115 - Sequence 305139 from Patent EP1572962.JD298412 - Sequence 279436 from Patent EP1572962.JD347121 - Sequence 328145 from Patent EP1572962.JD070718 - Sequence 51742 from Patent EP1572962.JD389719 - Sequence 370743 from Patent EP1572962.JD391611 - Sequence 372635 from Patent EP1572962.JD137484 - Sequence 118508 from Patent EP1572962.JD381078 - Sequence 362102 from Patent EP1572962.JD459872 - Sequence 440896 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04310 - Wnt signaling pathway
Other Names for This Gene
Alternate Gene Symbols: DAAM2_HUMAN, ENST00000274867.1, ENST00000274867.2, ENST00000274867.3, ENST00000274867.4, ENST00000274867.5, ENST00000274867.6, ENST00000274867.7, ENST00000274867.8, KIAA0381, NM_001201427, Q5T4T8, Q5T4U0, Q86T65, Q9NQI5, Q9Y4G0, uc003oow.1, uc003oow.2, uc003oow.3, uc003oow.4, uc003oow.5UCSC ID: ENST00000274867.9RefSeq Accession: NM_001201427
Protein: Q86T65
(aka DAAM2_HUMAN or DAM2_HUMAN)
CCDS: CCDS54999.1 , CCDS56426.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.