Human Gene NFYA (ENST00000341376.11) from GENCODE V44
Description: Homo sapiens nuclear transcription factor Y subunit alpha (NFYA), transcript variant 1, mRNA. (from RefSeq NM_002505) RefSeq Summary (NM_002505): The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000341376.11 Gencode Gene: ENSG00000001167.15 Transcript (Including UTRs) Position: hg38 chr6:41,072,974-41,102,403 Size: 29,430 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr6:41,079,090-41,097,410 Size: 18,321 Coding Exon Count: 9
ID:NFYA_HUMAN DESCRIPTION: RecName: Full=Nuclear transcription factor Y subunit alpha; AltName: Full=CAAT box DNA-binding protein subunit A; AltName: Full=Nuclear transcription factor Y subunit A; Short=NF-YA; FUNCTION: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. SUBUNIT: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3. INTERACTION: Q92624:APPBP2; NbExp=3; IntAct=EBI-389739, EBI-743771; P25208:NFYB; NbExp=4; IntAct=EBI-389739, EBI-389728; Q13952:NFYC; NbExp=3; IntAct=EBI-389739, EBI-389755; Q07955:SRSF1; NbExp=5; IntAct=EBI-389739, EBI-398920; P04637:TP53; NbExp=11; IntAct=EBI-389739, EBI-366083; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the NFYA/HAP2 subunit family. SIMILARITY: Contains 1 NFYA/HAP2-type DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02045 - CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
ModBase Predicted Comparative 3D Structure on P23511
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0045540 regulation of cholesterol biosynthetic process GO:0045893 positive regulation of transcription, DNA-templated GO:0048511 rhythmic process
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