Human Gene PAQR8 (ENST00000442253.3) from GENCODE V44
Description: Homo sapiens progestin and adipoQ receptor family member 8 (PAQR8), mRNA. (from RefSeq NM_133367)
Gencode Transcript: ENST00000442253.3
Gencode Gene: ENSG00000170915.9
Transcript (Including UTRs)
Position: hg38 chr6:52,362,151-52,407,777 Size: 45,627 Total Exon Count: 2 Strand: +
Coding Region
Position: hg38 chr6:52,403,214-52,404,278 Size: 1,065 Coding Exon Count: 1
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MPRB_HUMAN
DESCRIPTION: RecName: Full=Membrane progestin receptor beta; Short=mPR beta; AltName: Full=Lysosomal membrane protein in brain 1; AltName: Full=Progestin and adipoQ receptor family member 8; AltName: Full=Progestin and adipoQ receptor family member VIII;
FUNCTION: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity).SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Colocalizes with a lysosomal protein CTSD/cathepsin D.TISSUE SPECIFICITY: Expressed in brain and spinal cord. Also expressed in kidney and testis.SIMILARITY: Belongs to the ADIPOR family.SEQUENCE CAUTION: Sequence=AAR08374.1; Type=Erroneous initiation; Sequence=CAC05478.1; Type=Erroneous initiation;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR004254 - HlyIII-related
Pfam Domains: PF03006 - Haemolysin-III related
ModBase Predicted Comparative 3D Structure on Q8TEZ7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AF347029 - Homo sapiens transmembrane protein (C6ORF33) mRNA, complete cds.AK315088 - Homo sapiens cDNA, FLJ96045.BC030664 - Homo sapiens progestin and adipoQ receptor family member VIII, mRNA (cDNA clone MGC:33833 IMAGE:5260230), complete cds.AY424286 - Homo sapiens progestin and adipoQ receptor family member VIII (PAQR8) mRNA, complete cds.AK128085 - Homo sapiens cDNA FLJ46206 fis, clone TESTI4010721, highly similar to Membrane progestin receptor beta.JD024447 - Sequence 5471 from Patent EP1572962.CU688976 - Synthetic construct Homo sapiens gateway clone IMAGE:100019059 5' read PAQR8 mRNA.HQ447802 - Synthetic construct Homo sapiens clone IMAGE:100071145; CCSB001899_04 progestin and adipoQ receptor family member VIII (PAQR8) gene, encodes complete protein.KJ899860 - Synthetic construct Homo sapiens clone ccsbBroadEn_09254 PAQR8 gene, encodes complete protein.JD030640 - Sequence 11664 from Patent EP1572962.JD021948 - Sequence 2972 from Patent EP1572962.JD029303 - Sequence 10327 from Patent EP1572962.AK093603 - Homo sapiens cDNA FLJ36284 fis, clone THYMU2003446.AF313619 - Homo sapiens putative membrane steroid receptor mRNA, partial cds.JD333657 - Sequence 314681 from Patent EP1572962.JD326982 - Sequence 308006 from Patent EP1572962.JD302298 - Sequence 283322 from Patent EP1572962.JD565476 - Sequence 546500 from Patent EP1572962.JD110460 - Sequence 91484 from Patent EP1572962.JD237235 - Sequence 218259 from Patent EP1572962.JD540021 - Sequence 521045 from Patent EP1572962.JD496333 - Sequence 477357 from Patent EP1572962.JD554187 - Sequence 535211 from Patent EP1572962.JD274309 - Sequence 255333 from Patent EP1572962.JD183521 - Sequence 164545 from Patent EP1572962.AK057083 - Homo sapiens cDNA FLJ32521 fis, clone SMINT1000178.JD410208 - Sequence 391232 from Patent EP1572962.JD229910 - Sequence 210934 from Patent EP1572962.JD285770 - Sequence 266794 from Patent EP1572962.DQ600148 - Homo sapiens piRNA piR-38214, complete sequence.JD385252 - Sequence 366276 from Patent EP1572962.JD448786 - Sequence 429810 from Patent EP1572962.JD110806 - Sequence 91830 from Patent EP1572962.JD307690 - Sequence 288714 from Patent EP1572962.JD524841 - Sequence 505865 from Patent EP1572962.JD122426 - Sequence 103450 from Patent EP1572962.JD341667 - Sequence 322691 from Patent EP1572962.JD521949 - Sequence 502973 from Patent EP1572962.JD551109 - Sequence 532133 from Patent EP1572962.JD164888 - Sequence 145912 from Patent EP1572962.JD438614 - Sequence 419638 from Patent EP1572962.JD300889 - Sequence 281913 from Patent EP1572962.JD549437 - Sequence 530461 from Patent EP1572962.JD314687 - Sequence 295711 from Patent EP1572962.JD057631 - Sequence 38655 from Patent EP1572962.JD234487 - Sequence 215511 from Patent EP1572962.JD559896 - Sequence 540920 from Patent EP1572962.JD339503 - Sequence 320527 from Patent EP1572962.JD440626 - Sequence 421650 from Patent EP1572962.JD223456 - Sequence 204480 from Patent EP1572962.JD349633 - Sequence 330657 from Patent EP1572962.JD229365 - Sequence 210389 from Patent EP1572962.JD523043 - Sequence 504067 from Patent EP1572962.JD267866 - Sequence 248890 from Patent EP1572962.JD084236 - Sequence 65260 from Patent EP1572962.JD247132 - Sequence 228156 from Patent EP1572962.JD100764 - Sequence 81788 from Patent EP1572962.JD413815 - Sequence 394839 from Patent EP1572962.JD367647 - Sequence 348671 from Patent EP1572962.JD535477 - Sequence 516501 from Patent EP1572962.JD323164 - Sequence 304188 from Patent EP1572962.JD224632 - Sequence 205656 from Patent EP1572962.JD285540 - Sequence 266564 from Patent EP1572962.JD342375 - Sequence 323399 from Patent EP1572962.JD529903 - Sequence 510927 from Patent EP1572962.JD435398 - Sequence 416422 from Patent EP1572962.JD308101 - Sequence 289125 from Patent EP1572962.AJ420470 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1058423.JD312510 - Sequence 293534 from Patent EP1572962.JD316744 - Sequence 297768 from Patent EP1572962.JD299324 - Sequence 280348 from Patent EP1572962.JD353861 - Sequence 334885 from Patent EP1572962.JD442457 - Sequence 423481 from Patent EP1572962.JD339689 - Sequence 320713 from Patent EP1572962.JD205298 - Sequence 186322 from Patent EP1572962.JD187847 - Sequence 168871 from Patent EP1572962.JD050736 - Sequence 31760 from Patent EP1572962.JD310669 - Sequence 291693 from Patent EP1572962.JD486658 - Sequence 467682 from Patent EP1572962.JD553519 - Sequence 534543 from Patent EP1572962.JD537502 - Sequence 518526 from Patent EP1572962.JD489730 - Sequence 470754 from Patent EP1572962.JD241150 - Sequence 222174 from Patent EP1572962.JD289802 - Sequence 270826 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: B2RCF6, C6orf33, ENST00000442253.1, ENST00000442253.2, LMPB1, MPRB, MPRB_HUMAN, NM_133367, Q86WL0, Q8N6D3, Q8TEZ7, Q9HD02, uc003pao.1, uc003pao.2, uc003pao.3, uc003pao.4, uc003pao.5UCSC ID: ENST00000442253.3RefSeq Accession: NM_133367
Protein: Q8TEZ7
(aka MPRB_HUMAN)
CCDS: CCDS4941.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.