Human Gene OOEP (ENST00000370359.6) from GENCODE V44
  Description: Homo sapiens oocyte expressed protein (OOEP), mRNA. (from RefSeq NM_001080507)
Gencode Transcript: ENST00000370359.6
Gencode Gene: ENSG00000203907.10
Transcript (Including UTRs)
   Position: hg38 chr6:73,368,555-73,369,897 Size: 1,343 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr6:73,368,784-73,369,792 Size: 1,009 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:73,368,555-73,369,897)mRNA (may differ from genome)Protein (149 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDMalacardsMGIneXtProtOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OOEP_HUMAN
DESCRIPTION: RecName: Full=Oocyte-expressed protein homolog; AltName: Full=KH homology domain-containing protein 2; AltName: Full=Oocyte- and embryo-specific protein 19; Short=hOEP19;
FUNCTION: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity).
SUBUNIT: Component of the SCMC which also includes at least NLRP5 and TLE6 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity).
DOMAIN: Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.
SIMILARITY: Belongs to the KHDC1 family.
SIMILARITY: Contains 1 KH domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.07 RPKM in Testis
Total median expression: 16.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.90105-0.342 Picture PostScript Text
3' UTR -37.30229-0.163 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on A6NGQ2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005737 cytoplasm
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  BC024931 - Homo sapiens cDNA clone IMAGE:3918981, partial cds.
EU290647 - Homo sapiens oocyte and embryo protein 19 mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NGQ2, A6NIN5, A9UIB7, C6orf156, ENST00000370359.1, ENST00000370359.2, ENST00000370359.3, ENST00000370359.4, ENST00000370359.5, KHDC2, NM_001080507, OEP19, OOEP_HUMAN, uc003pgu.1, uc003pgu.2, uc003pgu.3, uc003pgu.4, uc003pgu.5, uc003pgu.6
UCSC ID: ENST00000370359.6
RefSeq Accession: NM_001080507
Protein: A6NGQ2 (aka OOEP_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.