Human Gene CALHM4 (ENST00000368597.6) from GENCODE V44
  Description: Homo sapiens calcium homeostasis modulator family member 4 (CALHM4), transcript variant 3, mRNA. (from RefSeq NM_153036)
Gencode Transcript: ENST00000368597.6
Gencode Gene: ENSG00000164451.14
Transcript (Including UTRs)
   Position: hg38 chr6:116,529,032-116,558,868 Size: 29,837 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr6:116,557,825-116,558,211 Size: 387 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:116,529,032-116,558,868)mRNA (may differ from genome)Protein (128 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD
LynxMGIneXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FA26D_HUMAN
DESCRIPTION: RecName: Full=Protein FAM26D;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the FAM26 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.15 RPKM in Testis
Total median expression: 0.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.60267-0.257 Picture PostScript Text
3' UTR -129.40657-0.197 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q5JW98
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005261 cation channel activity

Biological Process:
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
GO:0098655 cation transmembrane transport

Cellular Component:
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK300309 - Homo sapiens cDNA FLJ54850 complete cds.
AY358252 - Homo sapiens clone DNA167982 LGWI6481 (UNQ6481) mRNA, complete cds.
BC057769 - Homo sapiens family with sequence similarity 26, member D, mRNA (cDNA clone MGC:71530 IMAGE:30332648), complete cds.
AK056801 - Homo sapiens cDNA FLJ32239 fis, clone PLACE6005029.
JD494970 - Sequence 475994 from Patent EP1572962.
JD363949 - Sequence 344973 from Patent EP1572962.
JD165364 - Sequence 146388 from Patent EP1572962.
JD196614 - Sequence 177638 from Patent EP1572962.
JD047815 - Sequence 28839 from Patent EP1572962.
JD452186 - Sequence 433210 from Patent EP1572962.
JD114422 - Sequence 95446 from Patent EP1572962.
JD326272 - Sequence 307296 from Patent EP1572962.
JD304193 - Sequence 285217 from Patent EP1572962.
JD164538 - Sequence 145562 from Patent EP1572962.
JD382026 - Sequence 363050 from Patent EP1572962.
JD296831 - Sequence 277855 from Patent EP1572962.
JD503004 - Sequence 484028 from Patent EP1572962.
JD404217 - Sequence 385241 from Patent EP1572962.
JD436882 - Sequence 417906 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B0QZ25, B0QZ27, C6orf78, ENST00000368597.1, ENST00000368597.2, ENST00000368597.3, ENST00000368597.4, ENST00000368597.5, FA26D_HUMAN, FAM26D, NM_153036, Q5JW98, Q96MK0, uc003pwz.1, uc003pwz.2, uc003pwz.3, uc003pwz.4, uc003pwz.5, UNQ6481/PRO21277
UCSC ID: ENST00000368597.6
RefSeq Accession: NM_153036
Protein: Q5JW98 (aka FA26D_HUMAN)
CCDS: CCDS5109.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.