Human Gene PKIB (ENST00000392491.6) from GENCODE V44
Description: Homo sapiens cAMP-dependent protein kinase inhibitor beta (PKIB), transcript variant 2, mRNA. (from RefSeq NM_181794) RefSeq Summary (NM_181794): This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]. Gencode Transcript: ENST00000392491.6 Gencode Gene: ENSG00000135549.16 Transcript (Including UTRs) Position: hg38 chr6:122,471,931-122,725,890 Size: 253,960 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr6:122,717,795-122,725,195 Size: 7,401 Coding Exon Count: 2
ID:IPKB_HUMAN DESCRIPTION: RecName: Full=cAMP-dependent protein kinase inhibitor beta; Short=PKI-beta; FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains (By similarity). SIMILARITY: Belongs to the PKI family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02827 - cAMP-dependent protein kinase inhibitor
ModBase Predicted Comparative 3D Structure on Q9C010
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004860 protein kinase inhibitor activity GO:0004862 cAMP-dependent protein kinase inhibitor activity
Biological Process: GO:0006469 negative regulation of protein kinase activity GO:0032212 positive regulation of telomere maintenance via telomerase GO:0051973 positive regulation of telomerase activity GO:1904355 positive regulation of telomere capping GO:2000480 negative regulation of cAMP-dependent protein kinase activity
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
