ID:E41L2_HUMAN DESCRIPTION: RecName: Full=Band 4.1-like protein 2; AltName: Full=Generally expressed protein 4.1; Short=4.1G; SUBUNIT: Interacts with FCGR1A. Interacts with TRPC4. The CTD domain interacts with FKBP2 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cell membrane. TISSUE SPECIFICITY: Widely expressed. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 FERM domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05902 - 4.1 protein C-terminal domain (CTD) PF08736 - FERM adjacent (FA) PF09380 - FERM C-terminal PH-like domain PF00373 - FERM central domain PF09379 - FERM N-terminal domain PF04382 - SAB domain
ModBase Predicted Comparative 3D Structure on O43491
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
