ID:E41L2_HUMAN DESCRIPTION: RecName: Full=Band 4.1-like protein 2; AltName: Full=Generally expressed protein 4.1; Short=4.1G; SUBUNIT: Interacts with FCGR1A. Interacts with TRPC4. The CTD domain interacts with FKBP2 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cell membrane. TISSUE SPECIFICITY: Widely expressed. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 FERM domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05902 - 4.1 protein C-terminal domain (CTD) PF08736 - FERM adjacent (FA) PF09380 - FERM C-terminal PH-like domain PF00373 - FERM central domain PF09379 - FERM N-terminal domain PF04382 - SAB domain
ModBase Predicted Comparative 3D Structure on O43491
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.