Human Gene ZDHHC14 (ENST00000414563.6) from GENCODE V44
  Description: Homo sapiens zinc finger DHHC-type palmitoyltransferase 14 (ZDHHC14), transcript variant 2, mRNA. (from RefSeq NM_153746)
Gencode Transcript: ENST00000414563.6
Gencode Gene: ENSG00000175048.17
Transcript (Including UTRs)
   Position: hg38 chr6:157,381,133-157,673,945 Size: 292,813 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr6:157,382,022-157,673,122 Size: 291,101 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:157,381,133-157,673,945)mRNA (may differ from genome)Protein (473 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZDH14_HUMAN
DESCRIPTION: RecName: Full=Probable palmitoyltransferase ZDHHC14; EC=2.3.1.-; AltName: Full=NEW1 domain-containing protein; Short=NEW1CP; AltName: Full=Zinc finger DHHC domain-containing protein 14; Short=DHHC-14;
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
SIMILARITY: Contains 1 DHHC-type zinc finger.
SEQUENCE CAUTION: Sequence=BAB14941.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZDHHC14
Diseases sorted by gene-association score: chromosome 6q24-q25 deletion syndrome (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.87 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 154.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -556.90889-0.626 Picture PostScript Text
3' UTR -276.00823-0.335 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on Q8IZN3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016409 palmitoyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Biological Process:
GO:0018345 protein palmitoylation

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF542388 - Homo sapiens NEW1 domain containing protein mRNA, complete cds; alternatively spliced.
AF542389 - Homo sapiens NEW1 domain containing protein isoform mRNA, complete cds; alternatively spliced.
BC125072 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:40117634), partial cds.
BC125073 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:40117635), partial cds.
AB527626 - Synthetic construct DNA, clone: pF1KB3587, Homo sapiens ZDHHC14 gene for zinc finger, DHHC-type containing 14, without stop codon, in Flexi system.
AK309408 - Homo sapiens cDNA, FLJ99449.
BC029881 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:5171686).
AK124573 - Homo sapiens cDNA FLJ42582 fis, clone BRACE3008772, highly similar to Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.-).
AK128773 - Homo sapiens cDNA FLJ45379 fis, clone BRHIP3020155.
AK092380 - Homo sapiens cDNA FLJ35061 fis, clone OCBBF2018934, highly similar to Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.-).
AK024637 - Homo sapiens cDNA: FLJ20984 fis, clone CAE00871.
JD541552 - Sequence 522576 from Patent EP1572962.
BC008978 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:4156845).
BC056399 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:5735133), partial cds.
AK125148 - Homo sapiens cDNA FLJ43158 fis, clone ERLTF2000324.
JD370011 - Sequence 351035 from Patent EP1572962.
AK091628 - Homo sapiens cDNA FLJ34309 fis, clone FEBRA2008165.
AJ420552 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1666986.
JD414593 - Sequence 395617 from Patent EP1572962.
JD332650 - Sequence 313674 from Patent EP1572962.
JD381781 - Sequence 362805 from Patent EP1572962.
JD358763 - Sequence 339787 from Patent EP1572962.
JD448734 - Sequence 429758 from Patent EP1572962.
JD172466 - Sequence 153490 from Patent EP1572962.
JD109270 - Sequence 90294 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NDB7, ENST00000414563.1, ENST00000414563.2, ENST00000414563.3, ENST00000414563.4, ENST00000414563.5, NM_153746, Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q8IZN3, Q9H7F1, uc003qqs.1, uc003qqs.2, uc003qqs.3, uc003qqs.4, ZDH14_HUMAN
UCSC ID: ENST00000414563.6
RefSeq Accession: NM_024630
Protein: Q8IZN3 (aka ZDH14_HUMAN or ZDHE_HUMAN)
CCDS: CCDS5252.1, CCDS47510.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.