Human Gene ZDHHC14 (ENST00000414563.6) from GENCODE V44
Description: Homo sapiens zinc finger DHHC-type palmitoyltransferase 14 (ZDHHC14), transcript variant 2, mRNA. (from RefSeq NM_153746)
Gencode Transcript: ENST00000414563.6
Gencode Gene: ENSG00000175048.17
Transcript (Including UTRs)
Position: hg38 chr6:157,381,133-157,673,945 Size: 292,813 Total Exon Count: 9 Strand: +
Coding Region
Position: hg38 chr6:157,382,022-157,673,122 Size: 291,101 Coding Exon Count: 9
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: ZDH14_HUMAN
DESCRIPTION: RecName: Full=Probable palmitoyltransferase ZDHHC14; EC=2.3.1.-; AltName: Full=NEW1 domain-containing protein; Short=NEW1CP; AltName: Full=Zinc finger DHHC domain-containing protein 14; Short=DHHC-14;
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.SIMILARITY: Contains 1 DHHC-type zinc finger.SEQUENCE CAUTION: Sequence=BAB14941.1; Type=Erroneous initiation;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001594 - Znf_DHHC_palmitoyltrfase
Pfam Domains: PF01529 - DHHC palmitoyltransferase
ModBase Predicted Comparative 3D Structure on Q8IZN3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AF542388 - Homo sapiens NEW1 domain containing protein mRNA, complete cds; alternatively spliced.AF542389 - Homo sapiens NEW1 domain containing protein isoform mRNA, complete cds; alternatively spliced.BC125072 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:40117634), partial cds.BC125073 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:40117635), partial cds.AB527626 - Synthetic construct DNA, clone: pF1KB3587, Homo sapiens ZDHHC14 gene for zinc finger, DHHC-type containing 14, without stop codon, in Flexi system.AK309408 - Homo sapiens cDNA, FLJ99449.BC029881 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:5171686).AK124573 - Homo sapiens cDNA FLJ42582 fis, clone BRACE3008772, highly similar to Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.-).AK128773 - Homo sapiens cDNA FLJ45379 fis, clone BRHIP3020155.AK092380 - Homo sapiens cDNA FLJ35061 fis, clone OCBBF2018934, highly similar to Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.-).AK024637 - Homo sapiens cDNA: FLJ20984 fis, clone CAE00871.JD541552 - Sequence 522576 from Patent EP1572962.BC008978 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:4156845).BC056399 - Homo sapiens zinc finger, DHHC-type containing 14, mRNA (cDNA clone IMAGE:5735133), partial cds.AK125148 - Homo sapiens cDNA FLJ43158 fis, clone ERLTF2000324.JD370011 - Sequence 351035 from Patent EP1572962.AK091628 - Homo sapiens cDNA FLJ34309 fis, clone FEBRA2008165.AJ420552 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1666986.JD414593 - Sequence 395617 from Patent EP1572962.JD332650 - Sequence 313674 from Patent EP1572962.JD381781 - Sequence 362805 from Patent EP1572962.JD358763 - Sequence 339787 from Patent EP1572962.JD448734 - Sequence 429758 from Patent EP1572962.JD172466 - Sequence 153490 from Patent EP1572962.JD109270 - Sequence 90294 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A6NDB7, ENST00000414563.1, ENST00000414563.2, ENST00000414563.3, ENST00000414563.4, ENST00000414563.5, NM_153746, Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q8IZN3, Q9H7F1, uc003qqs.1, uc003qqs.2, uc003qqs.3, uc003qqs.4, ZDH14_HUMANUCSC ID: ENST00000414563.6RefSeq Accession: NM_024630
Protein: Q8IZN3
(aka ZDH14_HUMAN or ZDHE_HUMAN)
CCDS: CCDS5252.1 , CCDS47510.1
Methods, Credits, and Use Restrictions
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