Human Gene FSCN1 (ENST00000382361.8) from GENCODE V44
Description: Homo sapiens fascin actin-bundling protein 1 (FSCN1), mRNA. (from RefSeq NM_003088) RefSeq Summary (NM_003088): This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000382361.8 Gencode Gene: ENSG00000075618.18 Transcript (Including UTRs) Position: hg38 chr7:5,592,816-5,606,655 Size: 13,840 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr7:5,592,937-5,605,474 Size: 12,538 Coding Exon Count: 5
ID:FSCN1_HUMAN DESCRIPTION: RecName: Full=Fascin; AltName: Full=55 kDa actin-bundling protein; AltName: Full=Singed-like protein; AltName: Full=p55; FUNCTION: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. SUBUNIT: Associates with beta-catenin. Interacts with PLXNB3. INTERACTION: Q9BXW9:FANCD2; NbExp=6; IntAct=EBI-351076, EBI-359343; P40692:MLH1; NbExp=7; IntAct=EBI-351076, EBI-744248; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: Composed of four beta-trefoil domains. PTM: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin. SIMILARITY: Belongs to the fascin family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FSCN1ID44342ch7p22.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16658
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
