Human Gene AIMP2 (ENST00000223029.8) from GENCODE V44
Description: Homo sapiens aminoacyl tRNA synthetase complex interacting multifunctional protein 2 (AIMP2), transcript variant 1, mRNA. (from RefSeq NM_006303) RefSeq Summary (NM_006303): The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]. Gencode Transcript: ENST00000223029.8 Gencode Gene: ENSG00000106305.10 Transcript (Including UTRs) Position: hg38 chr7:6,009,272-6,023,834 Size: 14,563 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr7:6,009,364-6,023,691 Size: 14,328 Coding Exon Count: 4
ID:AIMP2_HUMAN DESCRIPTION: RecName: Full=Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; AltName: Full=Multisynthase complex auxiliary component p38; AltName: Full=Protein JTV-1; FUNCTION: Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. SUBUNIT: Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain). INTERACTION: Q0VDD7:C19orf57; NbExp=4; IntAct=EBI-745226, EBI-741210; P04591:gag (xeno); NbExp=3; IntAct=EBI-745226, EBI-6179719; SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus (By similarity). PTM: Phosphorylated on serine residues in response to UV irradiation (By similarity). PTM: Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease. MISCELLANEOUS: Accumulates in brains affected by autosomal- recessive juvenile parkinsonism, idiopathic Parkinson disease and diffuse Lewy body disease. SIMILARITY: Contains 1 GST C-terminal domain. SEQUENCE CAUTION: Sequence=AAC50391.1; Type=Frameshift; Positions=312;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13155
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0032947 protein complex scaffold
Biological Process: GO:0006412 translation GO:0006418 tRNA aminoacylation for protein translation GO:0006915 apoptotic process GO:0007275 multicellular organism development GO:0008285 negative regulation of cell proliferation GO:0030154 cell differentiation GO:0031398 positive regulation of protein ubiquitination GO:0060510 Type II pneumocyte differentiation GO:0065003 macromolecular complex assembly GO:1901216 positive regulation of neuron death GO:1903632 positive regulation of aminoacyl-tRNA ligase activity
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