Human Gene AGR3 (ENST00000310398.7) from GENCODE V44
Description: Homo sapiens anterior gradient 3, protein disulphide isomerase family member (AGR3), mRNA. (from RefSeq NM_176813) RefSeq Summary (NM_176813): This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]. Gencode Transcript: ENST00000310398.7 Gencode Gene: ENSG00000173467.9 Transcript (Including UTRs) Position: hg38 chr7:16,859,412-16,881,983 Size: 22,572 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr7:16,859,582-16,878,618 Size: 19,037 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TD06
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.