Human Gene CAMK2B (uc003tkr.2) Description and Page Index
  Description: Homo sapiens calcium/calmodulin-dependent protein kinase II beta (CAMK2B), transcript variant 3, mRNA.
RefSeq Summary (NM_172079): The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
Transcript (Including UTRs)
   Position: hg19 chr7:44,256,749-44,365,230 Size: 108,482 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg19 chr7:44,259,661-44,365,020 Size: 105,360 Coding Exon Count: 19 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:44,256,749-44,365,230)mRNA (may differ from genome)Protein (518 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CAMK2B
CDC HuGE Published Literature: CAMK2B
Positive Disease Associations: Metabolic Syndrome X
Related Studies:
  1. Metabolic Syndrome X
    Kati Kristiansson et al. Circulation. Cardiovascular genetics 2012, Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits., Circulation. Cardiovascular genetics. [PubMed 22399527]
    Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and glucose intolerance.

-  MalaCards Disease Associations
  MalaCards Gene Search: CAMK2B
Diseases sorted by gene-association score: phencyclidine abuse (10)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 108.20 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 696.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -118.80210-0.566 Picture PostScript Text
3' UTR -1022.742375-0.431 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF08332 - Calcium/calmodulin dependent protein kinase II association domain
PF13474 - SnoaL-like domain
PF14534 - Domain of unknown function (DUF4440)

SCOP Domains:
47473 - EF-hand
56112 - Protein kinase-like (PK-like)
54427 - NTF2-like

ModBase Predicted Comparative 3D Structure on Q13554-5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  AK290148 - Homo sapiens cDNA FLJ75317 complete cds, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase (CaM kinase) II beta (CAMK2B), transcript variant 2, mRNA.
AK294138 - Homo sapiens cDNA FLJ58056 complete cds, highly similar to Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17).
AJ252237 - Homo sapiens mRNA for calcium/calmodulin dependent protein kinase II beta 2 (CaMK II beta 2 gene).
AJ252236 - Homo sapiens mRNA for calcium/calmodulin dependent protein kinase II beta 1 (CaMK II beta 1 gene).
BC019070 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta, mRNA (cDNA clone MGC:29528 IMAGE:5014712), complete cds.
AK222703 - Homo sapiens mRNA for calcium/calmodulin-dependent protein kinase IIB isoform 2 variant, clone: CBR08526.
AF112471 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta subunit mRNA, alternatively spliced, complete cds.
AF112472 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta subunit mRNA, complete cds.
U23460 - Human proline rich calmodulin-dependent protein kinase mRNA, complete cds.
AF078803 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta subunit mRNA, complete cds.
AF081572 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta e' subunit (CAMKB) mRNA, complete cds.
AF081924 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta 6 subunit (CAMKB) mRNA, complete cds.
AF083419 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta e subunit (CAMKB) mRNA, complete cds.
AF140350 - Homo sapiens calcium/calmodulin-dependent protein kinase II beta 7 subunit (CAM2) mRNA, complete cds.
AM392749 - Synthetic construct Homo sapiens clone IMAGE:100002998 for hypothetical protein (CAMK2B gene).
AM393817 - Synthetic construct Homo sapiens clone IMAGE:100002997 for hypothetical protein (CAMK2B gene).
AJ252238 - Homo sapiens mRNA for calcium/calmodulin dependent protein kinase II beta 4 (CaMK II beta 4 gene).
AK315663 - Homo sapiens cDNA, FLJ96755, Homo sapiens calcium/calmodulin-dependent protein kinase (CaMkinase) II beta (CAMK2B), transcript variant 5, mRNA.
KJ905157 - Synthetic construct Homo sapiens clone ccsbBroadEn_14563 CAMK2B gene, encodes complete protein.
KJ905158 - Synthetic construct Homo sapiens clone ccsbBroadEn_14564 CAMK2B gene, encodes complete protein.
AM392792 - Synthetic construct Homo sapiens clone IMAGE:100002747 for hypothetical protein (CAMK2B gene).
AM393562 - Synthetic construct Homo sapiens clone IMAGE:100002748 for hypothetical protein (CAMK2B gene).
AB462968 - Synthetic construct DNA, clone: pF1KB8435, Homo sapiens CAMK2B gene for calcium/calmodulin-dependent protein kinase (CaM kinase) II beta, without stop codon, in Flexi system.
CU676368 - Synthetic construct Homo sapiens gateway clone IMAGE:100019704 5' read CAMK2B mRNA.
AB073352 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla00715, full insert sequence.
AF131776 - Homo sapiens clone 25048 mRNA sequence.
AK091991 - Homo sapiens cDNA FLJ34672 fis, clone LIVER2001164, highly similar to Human proline rich calmodulin-dependent protein kinase mRNA.
AX747297 - Sequence 822 from Patent EP1308459.
JD257879 - Sequence 238903 from Patent EP1572962.
JD232709 - Sequence 213733 from Patent EP1572962.
JD100747 - Sequence 81771 from Patent EP1572962.
U50358 - Human calcium, calmodulin-dependent protein kinase II beta mRNA, partial cds.
JD128981 - Sequence 110005 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway
hsa04020 - Calcium signaling pathway
hsa04114 - Oocyte meiosis
hsa04310 - Wnt signaling pathway
hsa04720 - Long-term potentiation
hsa04722 - Neurotrophin signaling pathway
hsa04740 - Olfactory transduction
hsa04912 - GnRH signaling pathway
hsa04916 - Melanogenesis
hsa05214 - Glioma

Reactome (by CSHL, EBI, and GO)

Protein Q13554 (Reactome details) participates in the following event(s):

R-HSA-442725 Activation of CaMKII
R-HSA-445367 CaMKII enters cytoplasm
R-HSA-444792 CaMKII enters nucleus
R-HSA-416320 Trafficking of GluR1-containing AMPA receptors
R-HSA-5082387 Phosphorylation of HSF1 at Ser230 induces transactivation
R-HSA-443475 Phosphorylation of CREB by CaMKII
R-HSA-442726 Raf activation
R-HSA-432172 Activation of NMDA receptor
R-HSA-432162 Unblocking of NMDA receptor
R-HSA-909552 Phosphorylation of STAT1 at Ser727
R-HSA-442760 Activation of RasGRF
R-HSA-432164 Ca2+ influx into the post-synaptic cell
R-HSA-442732 Ras activation
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-438064 Post NMDA receptor activation events
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation
R-HSA-442755 Activation of NMDA receptor and postsynaptic events
R-HSA-3371556 Cellular response to heat stress
R-HSA-877300 Interferon gamma signaling
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-2262752 Cellular responses to stress
R-HSA-913531 Interferon Signaling
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-112316 Neuronal System
R-HSA-168256 Immune System
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: CAM2, CAMK2, CAMKB, NM_172079, NP_742076, Q13554-5
UCSC ID: uc003tkr.2
RefSeq Accession: NM_172079
Protein: Q13554-5, splice isoform of Q13554 CCDS: CCDS5484.1, CCDS5485.1, CCDS5486.1, CCDS43573.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_172079.2
exon count: 20CDS single in 3' UTR: no RNA size: 4142
ORF size: 1557CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3184.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.