Human Gene CDK14 (ENST00000380050.8) from GENCODE V44
  Description: Homo sapiens cyclin dependent kinase 14 (CDK14), transcript variant 1, mRNA. (from RefSeq NM_001287135)
RefSeq Summary (NM_001287135): PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008].
Gencode Transcript: ENST00000380050.8
Gencode Gene: ENSG00000058091.17
Transcript (Including UTRs)
   Position: hg38 chr7:90,596,321-91,210,590 Size: 614,270 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg38 chr7:90,596,628-91,118,180 Size: 521,553 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:90,596,321-91,210,590)mRNA (may differ from genome)Protein (469 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDK14_HUMAN
DESCRIPTION: RecName: Full=Cyclin-dependent kinase 14; EC=2.7.11.22; AltName: Full=Cell division protein kinase 14; AltName: Full=Serine/threonine-protein kinase PFTAIRE-1; Short=hPFTAIRE1;
FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A.
SUBUNIT: Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ.
INTERACTION: P30281:CCND3; NbExp=5; IntAct=EBI-1043945, EBI-375013; P38936:CDKN1A; NbExp=7; IntAct=EBI-1043945, EBI-375077; P31946:YWHAB; NbExp=5; IntAct=EBI-1043945, EBI-359815; P62258:YWHAE; NbExp=3; IntAct=EBI-1043945, EBI-356498; Q04917:YWHAH; NbExp=3; IntAct=EBI-1043945, EBI-306940; P27348:YWHAQ; NbExp=3; IntAct=EBI-1043945, EBI-359854;
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.
TISSUE SPECIFICITY: Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=BAA74857.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

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Click here to open Exonprimer with this transcript

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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.83 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 269.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -164.70307-0.536 Picture PostScript Text
3' UTR -900.603454-0.261 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on O94921
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0030332 cyclin binding

Biological Process:
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0016055 Wnt signaling pathway
GO:0016310 phosphorylation
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0060828 regulation of canonical Wnt signaling pathway

Cellular Component:
GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  DQ656060 - Homo sapiens clone UGL287-E-D4, mRNA sequence.
DQ655964 - Homo sapiens clone UGL15d02, mRNA sequence.
DQ655965 - Homo sapiens clone UGL15e02, mRNA sequence.
DQ655962 - Homo sapiens clone UGL15a02, mRNA sequence.
DQ655963 - Homo sapiens clone UGL15b02, mRNA sequence.
DQ655966 - Homo sapiens clone UGL15f02, mRNA sequence.
AK297974 - Homo sapiens cDNA FLJ53629 complete cds, highly similar to Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).
AF119833 - Homo sapiens serine/threonine protein kinase PFTAIRE-1 mRNA, complete cds.
AB020641 - Homo sapiens KIAA0834 mRNA for KIAA0834 protein.
BC152436 - Homo sapiens PFTAIRE protein kinase 1, mRNA (cDNA clone MGC:176679 IMAGE:8862558), complete cds.
BC167152 - Homo sapiens PFTAIRE protein kinase 1, mRNA (cDNA clone MGC:176668 IMAGE:8862547), complete cds.
BC167156 - Homo sapiens PFTAIRE protein kinase 1, mRNA (cDNA clone MGC:176691 IMAGE:8862570), complete cds.
BC136476 - Homo sapiens PFTAIRE protein kinase 1, mRNA (cDNA clone MGC:168088 IMAGE:9020465), complete cds.
BC136477 - Homo sapiens PFTAIRE protein kinase 1, mRNA (cDNA clone MGC:168089 IMAGE:9020466), complete cds.
AK289782 - Homo sapiens cDNA FLJ75582 complete cds, highly similar to Homo sapiens PFTAIRE protein kinase 1 (PFTK1), mRNA.
AB384534 - Synthetic construct DNA, clone: pF1KA0834, Homo sapiens PFTK1 gene for serine/threonine-protein kinase PFTAIRE-1, complete cds, without stop codon, in Flexi system.
BC152388 - Homo sapiens PFTAIRE protein kinase 1, mRNA (cDNA clone IMAGE:100013449).
AK295086 - Homo sapiens cDNA FLJ53325 complete cds, highly similar to Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).
AK307484 - Homo sapiens cDNA, FLJ97432.
AK296406 - Homo sapiens cDNA FLJ59558 complete cds, highly similar to Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).
AK316026 - Homo sapiens cDNA, FLJ78925 complete cds, highly similar to Serine/threonine-protein kinase PFTAIRE-1 (EC2.7.11.22).
JD067258 - Sequence 48282 from Patent EP1572962.
JD136930 - Sequence 117954 from Patent EP1572962.
JD089970 - Sequence 70994 from Patent EP1572962.
JD298879 - Sequence 279903 from Patent EP1572962.
JD094651 - Sequence 75675 from Patent EP1572962.
JD123388 - Sequence 104412 from Patent EP1572962.
JD341136 - Sequence 322160 from Patent EP1572962.
JD120091 - Sequence 101115 from Patent EP1572962.
JD300184 - Sequence 281208 from Patent EP1572962.
JD163794 - Sequence 144818 from Patent EP1572962.
JD393858 - Sequence 374882 from Patent EP1572962.
JD244163 - Sequence 225187 from Patent EP1572962.
JD090268 - Sequence 71292 from Patent EP1572962.
JD107234 - Sequence 88258 from Patent EP1572962.
JD122247 - Sequence 103271 from Patent EP1572962.
JD376520 - Sequence 357544 from Patent EP1572962.
JD434681 - Sequence 415705 from Patent EP1572962.
JD469638 - Sequence 450662 from Patent EP1572962.
JD355349 - Sequence 336373 from Patent EP1572962.
JD305098 - Sequence 286122 from Patent EP1572962.
JD170927 - Sequence 151951 from Patent EP1572962.
JD358951 - Sequence 339975 from Patent EP1572962.
JD350002 - Sequence 331026 from Patent EP1572962.
JD120394 - Sequence 101418 from Patent EP1572962.
JD390355 - Sequence 371379 from Patent EP1572962.
JD126630 - Sequence 107654 from Patent EP1572962.
JD519536 - Sequence 500560 from Patent EP1572962.
JD429417 - Sequence 410441 from Patent EP1572962.
JD551789 - Sequence 532813 from Patent EP1572962.
JD346051 - Sequence 327075 from Patent EP1572962.
JD109879 - Sequence 90903 from Patent EP1572962.
JD298199 - Sequence 279223 from Patent EP1572962.
JD315238 - Sequence 296262 from Patent EP1572962.
JD082651 - Sequence 63675 from Patent EP1572962.
JD289798 - Sequence 270822 from Patent EP1572962.
JD114973 - Sequence 95997 from Patent EP1572962.
JD437632 - Sequence 418656 from Patent EP1572962.
JD314156 - Sequence 295180 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D1E6, A6NK51, A8WFP6, B4DHG5, B4DNM2, CDK14_HUMAN, ENST00000380050.1, ENST00000380050.2, ENST00000380050.3, ENST00000380050.4, ENST00000380050.5, ENST00000380050.6, ENST00000380050.7, KIAA0834, NM_001287135, O94921, PFTK1, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0, uc003uky.1, uc003uky.2, uc003uky.3, uc003uky.4, uc003uky.5
UCSC ID: ENST00000380050.8
RefSeq Accession: NM_001287135
Protein: O94921 (aka CDK14_HUMAN)
CCDS: CCDS75626.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.