Human Gene FAM200A (ENST00000449309.2)
  Description: Homo sapiens family with sequence similarity 200 member A (FAM200A), mRNA. (from RefSeq NM_145111)
RefSeq Summary (NM_145111): This gene encodes a protein of unknown function. The protein is weakly similar to transposase-like proteins in human and mouse. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000449309.2
Gencode Gene: ENSG00000221909.3
Transcript (Including UTRs)
   Position: hg38 chr7:99,546,300-99,552,114 Size: 5,815 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr7:99,546,686-99,548,407 Size: 1,722 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:99,546,300-99,552,114)mRNA (may differ from genome)Protein (573 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein FAM200A;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the FAM200 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.46 RPKM in Testis
Total median expression: 142.28 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -127.80360-0.355 Picture PostScript Text
3' UTR -106.80386-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025398 - DUF4371
IPR012337 - RNaseH-like_dom

Pfam Domains:
PF14291 - Domain of unknown function (DUF4371)

ModBase Predicted Comparative 3D Structure on Q8TCP9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK024526 - Homo sapiens cDNA: FLJ20873 fis, clone ADKA02669.
AL713672 - Homo sapiens mRNA; cDNA DKFZp727G131 (from clone DKFZp727G131).
BC040214 - Homo sapiens chromosome 7 open reading frame 38, mRNA (cDNA clone MGC:36754 IMAGE:5166971), complete cds.
AK290724 - Homo sapiens cDNA FLJ77794 complete cds.
JD117060 - Sequence 98084 from Patent EP1572962.
JD113355 - Sequence 94379 from Patent EP1572962.
JD269128 - Sequence 250152 from Patent EP1572962.
JD156651 - Sequence 137675 from Patent EP1572962.
JD105853 - Sequence 86877 from Patent EP1572962.
JD117059 - Sequence 98083 from Patent EP1572962.
JD517539 - Sequence 498563 from Patent EP1572962.
JD085822 - Sequence 66846 from Patent EP1572962.
JD047488 - Sequence 28512 from Patent EP1572962.
JD331497 - Sequence 312521 from Patent EP1572962.
JD176434 - Sequence 157458 from Patent EP1572962.
JD528279 - Sequence 509303 from Patent EP1572962.
JD294758 - Sequence 275782 from Patent EP1572962.
JD453862 - Sequence 434886 from Patent EP1572962.
JD274663 - Sequence 255687 from Patent EP1572962.
JD193806 - Sequence 174830 from Patent EP1572962.
JD193807 - Sequence 174831 from Patent EP1572962.
JD537004 - Sequence 518028 from Patent EP1572962.
JD412003 - Sequence 393027 from Patent EP1572962.
JD376802 - Sequence 357826 from Patent EP1572962.
JD167582 - Sequence 148606 from Patent EP1572962.
JD376161 - Sequence 357185 from Patent EP1572962.
JD068938 - Sequence 49962 from Patent EP1572962.
JD238269 - Sequence 219293 from Patent EP1572962.
JD406483 - Sequence 387507 from Patent EP1572962.
JD283400 - Sequence 264424 from Patent EP1572962.
BC130371 - Homo sapiens chromosome 7 open reading frame 38, mRNA (cDNA clone MGC:163243 IMAGE:40146402), complete cds.
BC126337 - Homo sapiens chromosome 7 open reading frame 38, mRNA (cDNA clone MGC:161615 IMAGE:8992053), complete cds.
JD543965 - Sequence 524989 from Patent EP1572962.
JD384727 - Sequence 365751 from Patent EP1572962.
JD543964 - Sequence 524988 from Patent EP1572962.
JD498026 - Sequence 479050 from Patent EP1572962.
JD498027 - Sequence 479051 from Patent EP1572962.
JD222986 - Sequence 204010 from Patent EP1572962.
JD112450 - Sequence 93474 from Patent EP1572962.
JD222985 - Sequence 204009 from Patent EP1572962.
JD089548 - Sequence 70572 from Patent EP1572962.
JD279114 - Sequence 260138 from Patent EP1572962.
JD231942 - Sequence 212966 from Patent EP1572962.
JD223822 - Sequence 204846 from Patent EP1572962.
JD103026 - Sequence 84050 from Patent EP1572962.
AK315452 - Homo sapiens cDNA, FLJ96510.
HQ258461 - Synthetic construct Homo sapiens clone IMAGE:100072890 family with sequence similarity 200, member A (FAM200A) gene, encodes complete protein.
HQ258625 - Synthetic construct Homo sapiens clone IMAGE:100073179 family with sequence similarity 200, member A (FAM200A) gene, encodes complete protein.
KJ900482 - Synthetic construct Homo sapiens clone ccsbBroadEn_09876 FAM200A gene, encodes complete protein.
KJ895871 - Synthetic construct Homo sapiens clone ccsbBroadEn_05265 FAM200A gene, encodes complete protein.
AK094113 - Homo sapiens cDNA FLJ36794 fis, clone ADRGL2006193, weakly similar to Transposon-derived Buster1 transposase-like protein.
BC009536 - Homo sapiens chromosome 7 open reading frame 38, mRNA (cDNA clone IMAGE:3892368).
JD161257 - Sequence 142281 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D293, A8K3V9, B2RD92, C7orf38, C9J6A8, D6W5T2, ENST00000449309.1, F200A_HUMAN, NM_145111, Q8N9P3, Q8TCP9, uc003ura.1, uc003ura.2, uc003ura.3, uc003ura.4, uc003ura.5
UCSC ID: ENST00000449309.2
RefSeq Accession: NM_145111
Protein: Q8TCP9 (aka F200A_HUMAN)
CCDS: CCDS5668.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.