Human Gene NYAP1 (uc003uvd.2) Description and Page Index
  Description: Homo sapiens neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 (NYAP1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:100,081,550-100,092,424 Size: 10,875 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr7:100,082,935-100,091,526 Size: 8,592 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:100,081,550-100,092,424)mRNA (may differ from genome)Protein (841 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: NYAP1_HUMAN
DESCRIPTION: RecName: Full=Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1;
FUNCTION: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).
SUBUNIT: Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
PTM: Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5 (By similarity).
SIMILARITY: Belongs to the NYAP family.
SEQUENCE CAUTION: Sequence=BAC04437.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.43 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 301.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.30159-0.492 Picture PostScript Text
3' UTR -349.26898-0.389 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026724 - NYAP1
IPR026722 - NYAP1/NYAP2

Pfam Domains:
PF15439 - Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
PF15452 - Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

ModBase Predicted Comparative 3D Structure on Q6ZVC0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0048812 neuron projection morphogenesis

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  AK124773 - Homo sapiens cDNA FLJ42783 fis, clone BRAWH3005981.
BC041433 - Homo sapiens cDNA clone IMAGE:4938103, partial cds.
AK094857 - Homo sapiens cDNA FLJ37538 fis, clone BRCAN2023724.
JD210231 - Sequence 191255 from Patent EP1572962.
AY375450 - Homo sapiens unknown mRNA.
JD065593 - Sequence 46617 from Patent EP1572962.
JD157822 - Sequence 138846 from Patent EP1572962.
JD272306 - Sequence 253330 from Patent EP1572962.
JD265659 - Sequence 246683 from Patent EP1572962.
JD307513 - Sequence 288537 from Patent EP1572962.
JD111931 - Sequence 92955 from Patent EP1572962.
JD544923 - Sequence 525947 from Patent EP1572962.
JD064266 - Sequence 45290 from Patent EP1572962.
JD064184 - Sequence 45208 from Patent EP1572962.
JD445742 - Sequence 426766 from Patent EP1572962.
JD076782 - Sequence 57806 from Patent EP1572962.
JD527051 - Sequence 508075 from Patent EP1572962.
JD134182 - Sequence 115206 from Patent EP1572962.
JD337310 - Sequence 318334 from Patent EP1572962.
JD123175 - Sequence 104199 from Patent EP1572962.
JD496510 - Sequence 477534 from Patent EP1572962.
JD170607 - Sequence 151631 from Patent EP1572962.
JD565824 - Sequence 546848 from Patent EP1572962.
JD500898 - Sequence 481922 from Patent EP1572962.
JD268077 - Sequence 249101 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C7orf51, NM_173564, NP_775835, NYAP1_HUMAN, Q6U9Y3, Q6ZVC0, Q8N1V0, uc003uvd.1
UCSC ID: uc003uvd.2
RefSeq Accession: NM_173564
Protein: Q6ZVC0 (aka NYAP1_HUMAN)
CCDS: CCDS5696.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_173564.3
exon count: 7CDS single in 3' UTR: no RNA size: 3594
ORF size: 2526CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5140.00frame shift in genome: no % Coverage: 99.69
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.