ID:NYAP1_HUMAN DESCRIPTION: RecName: Full=Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; FUNCTION: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). SUBUNIT: Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity). PTM: Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5 (By similarity). SIMILARITY: Belongs to the NYAP family. SEQUENCE CAUTION: Sequence=BAC04437.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Highest median expression: 27.43 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 301.32 RPKM
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZVC0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.