Human Gene RASA4 (ENST00000262940.12) from GENCODE V44
Description: Homo sapiens RAS p21 protein activator 4 (RASA4), transcript variant 1, mRNA. (from RefSeq NM_006989) RefSeq Summary (NM_006989): This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000262940.12 Gencode Gene: ENSG00000105808.19 Transcript (Including UTRs) Position: hg38 chr7:102,579,646-102,616,756 Size: 37,111 Total Exon Count: 21 Strand: - Coding Region Position: hg38 chr7:102,582,771-102,616,689 Size: 33,919 Coding Exon Count: 21
ID:RASL2_HUMAN DESCRIPTION: RecName: Full=Ras GTPase-activating protein 4; AltName: Full=Calcium-promoted Ras inactivator; AltName: Full=Ras p21 protein activator 4; AltName: Full=RasGAP-activating-like protein 2; FUNCTION: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane. TISSUE SPECIFICITY: Widely expressed. DOMAIN: The PH domain does not bind phosphatidylinositol 4,5- bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members. SIMILARITY: Contains 1 Btk-type zinc finger. SIMILARITY: Contains 2 C2 domains. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 Ras-GAP domain. SEQUENCE CAUTION: Sequence=AAB97935.2; Type=Erroneous gene model prediction; Sequence=AAP22345.1; Type=Erroneous gene model prediction; Sequence=BAA25464.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00779 - BTK motif PF00168 - C2 domain PF00616 - GTPase-activator protein for Ras-like GTPase
ModBase Predicted Comparative 3D Structure on O43374
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0007165 signal transduction GO:0034260 negative regulation of GTPase activity GO:0035556 intracellular signal transduction GO:0043087 regulation of GTPase activity GO:0043547 positive regulation of GTPase activity GO:0046580 negative regulation of Ras protein signal transduction GO:0071277 cellular response to calcium ion
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