Human Gene CAV1 (ENST00000614113.5) from GENCODE V44
Description: caveolin 1 (from HGNC CAV1) RefSeq Summary (NM_001172895): The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]. Gencode Transcript: ENST00000614113.5 Gencode Gene: ENSG00000105974.13 Transcript (Including UTRs) Position: hg38 chr7:116,524,994-116,559,633 Size: 34,640 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr7:116,525,063-116,526,664 Size: 1,602 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
EF179101 - Homo sapiens clone D09 mRNA sequence. EF179102 - Homo sapiens clone H09 mRNA sequence. AK290871 - Homo sapiens cDNA FLJ76154 complete cds, highly similar to Homo sapiens caveolin 1, caveolae protein, 22kDa (CAV1), mRNA. BC009685 - Homo sapiens caveolin 1, caveolae protein, 22kDa, mRNA (cDNA clone IMAGE:3890183), complete cds. BC006432 - Homo sapiens caveolin 1, caveolae protein, 22kDa, mRNA (cDNA clone IMAGE:3689500), with apparent retained intron. JD317457 - Sequence 298481 from Patent EP1572962. AY762103 - Homo sapiens cell growth-inhibiting protein 32 mRNA, complete cds. Z18951 - H.sapiens mRNA for caveolin. BC082246 - Homo sapiens caveolin 1, caveolae protein, 22kDa, mRNA (cDNA clone MGC:99576 IMAGE:5441212), complete cds. DQ890647 - Synthetic construct clone IMAGE:100003277; FLH164759.01X; RZPDo839B08158D caveolin 1, caveolae protein, 22kDa (CAV1) gene, encodes complete protein. DQ893827 - Synthetic construct Homo sapiens clone IMAGE:100008287; FLH164755.01L; RZPDo839B08157D caveolin 1, caveolae protein, 22kDa (CAV1) gene, encodes complete protein. EU176473 - Synthetic construct Homo sapiens clone IMAGE:100011615; FLH263896.01L; RZPDo839F12247D caveolin 1, caveolae protein, 22kDa (CAV1) gene, encodes complete protein. KJ890832 - Synthetic construct Homo sapiens clone ccsbBroadEn_00226 CAV1 gene, encodes complete protein. AB489179 - Synthetic construct DNA, clone: pF1KE0218, Homo sapiens CAV1 gene for caveolin 1, caveolae protein, 22kDa, without stop codon, in Flexi system. AM393679 - Synthetic construct Homo sapiens clone IMAGE:100002558 for hypothetical protein (CAV1 gene). AB451416 - Homo sapiens CAV1 mRNA for caveolin 1, partial cds, clone: FLJ08122AAAF. BT007143 - Homo sapiens caveolin 1, caveolae protein, 22kDa mRNA, complete cds. AB451284 - Homo sapiens CAV1 mRNA for caveolin 1, complete cds, clone: FLJ08122AAAN. AK057982 - Homo sapiens cDNA FLJ25253 fis, clone STM03864, highly similar to CAVEOLIN-1. AF172085 - Homo sapiens MSTP085 mRNA, complete cds. AK307501 - Homo sapiens cDNA, FLJ97449. EF649773 - Homo sapiens caveolin-1 beta isoform protein mRNA, partial cds, alternatively spliced. EF649774 - Homo sapiens caveolin-1 beta isoform protein variant 1 mRNA, complete cds, alternatively spliced. AB209926 - Homo sapiens mRNA for caveolin 1 variant protein. JD228874 - Sequence 209898 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04144 - Endocytosis hsa04510 - Focal adhesion hsa05100 - Bacterial invasion of epithelial cells hsa05416 - Viral myocarditis
BioCarta from NCI Cancer Genome Anatomy Project h_integrinPathway - Integrin Signaling Pathway h_no1Pathway - Actions of Nitric Oxide in the Heart