Human Gene LSM8 (ENST00000249299.7) from GENCODE V44
Description: Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8), mRNA. (from RefSeq NM_016200) RefSeq Summary (NM_016200): This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000249299.7 Gencode Gene: ENSG00000128534.8 Transcript (Including UTRs) Position: hg38 chr7:118,184,164-118,204,035 Size: 19,872 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr7:118,184,224-118,192,002 Size: 7,779 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95777
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF207041 - JP 2014500723-A/14544: Polycomb-Associated Non-Coding RNAs. MA442618 - JP 2018138019-A/14544: Polycomb-Associated Non-Coding RNAs. BC042464 - Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae), mRNA (cDNA clone IMAGE:5163799), with apparent retained intron. AK311936 - Homo sapiens cDNA, FLJ92203, Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S.cerevisiae) (LSM8), mRNA. AF182294 - Homo sapiens U6 snRNA-associated Sm-like protein LSm8 mRNA, complete cds. BC045532 - Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae), mRNA (cDNA clone IMAGE:5268365), with apparent retained intron. BC053644 - Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae), mRNA (cDNA clone IMAGE:5212975), with apparent retained intron. BC022440 - Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae), mRNA (cDNA clone MGC:24761 IMAGE:4283482), complete cds. BC002742 - Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae), mRNA (cDNA clone MGC:3345 IMAGE:3626875), complete cds. BC064376 - Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae), mRNA (cDNA clone IMAGE:5723621), with apparent retained intron. AK090561 - Homo sapiens cDNA FLJ33242 fis, clone ASTRO2004051. LF360455 - JP 2014500723-A/167958: Polycomb-Associated Non-Coding RNAs. MA596032 - JP 2018138019-A/167958: Polycomb-Associated Non-Coding RNAs. LF360459 - JP 2014500723-A/167962: Polycomb-Associated Non-Coding RNAs. MA596036 - JP 2018138019-A/167962: Polycomb-Associated Non-Coding RNAs. JD301864 - Sequence 282888 from Patent EP1572962. JD504781 - Sequence 485805 from Patent EP1572962. JD305704 - Sequence 286728 from Patent EP1572962. LF360460 - JP 2014500723-A/167963: Polycomb-Associated Non-Coding RNAs. MA596037 - JP 2018138019-A/167963: Polycomb-Associated Non-Coding RNAs. JD351100 - Sequence 332124 from Patent EP1572962. JD519263 - Sequence 500287 from Patent EP1572962. JD490532 - Sequence 471556 from Patent EP1572962. JD551095 - Sequence 532119 from Patent EP1572962. LF360461 - JP 2014500723-A/167964: Polycomb-Associated Non-Coding RNAs. MA596038 - JP 2018138019-A/167964: Polycomb-Associated Non-Coding RNAs. JD071952 - Sequence 52976 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03018 - RNA degradation hsa03040 - Spliceosome
Reactome (by CSHL, EBI, and GO)
Protein O95777 (Reactome details) participates in the following event(s):
R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA