Human Gene SLC13A1 (ENST00000194130.7) from GENCODE V44
Description: Homo sapiens solute carrier family 13 member 1 (SLC13A1), transcript variant 1, mRNA. (from RefSeq NM_022444) RefSeq Summary (NM_022444): The protein encoded by this gene is an apical membrane Na(+)-sulfate cotransporter involved in sulfate homeostasis in the kidney. Defects in this gene lead to many pathophysiologic problems. [provided by RefSeq, May 2016]. Gencode Transcript: ENST00000194130.7 Gencode Gene: ENSG00000081800.9 Transcript (Including UTRs) Position: hg38 chr7:123,113,531-123,199,969 Size: 86,439 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr7:123,115,518-123,199,946 Size: 84,429 Coding Exon Count: 15
ID:S13A1_HUMAN DESCRIPTION: RecName: Full=Solute carrier family 13 member 1; AltName: Full=Renal sodium/sulfate cotransporter; Short=Na(+)/sulfate cotransporter; Short=hNaSi-1; FUNCTION: Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in kidney; not detectable in the other tissues tested. INDUCTION: Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate. SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00939 - Sodium:sulfate symporter transmembrane region
ModBase Predicted Comparative 3D Structure on Q9BZW2
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF260824 - Homo sapiens renal sodium/sulfate cotransporter mRNA, complete cds. JD126390 - Sequence 107414 from Patent EP1572962. AK026413 - Homo sapiens cDNA: FLJ22760 fis, clone KAIA0881. JD492872 - Sequence 473896 from Patent EP1572962. JD492950 - Sequence 473974 from Patent EP1572962. JD047370 - Sequence 28394 from Patent EP1572962. JD086770 - Sequence 67794 from Patent EP1572962. JD188455 - Sequence 169479 from Patent EP1572962. JD195307 - Sequence 176331 from Patent EP1572962. BC111775 - Homo sapiens solute carrier family 13 (sodium/sulfate symporters), member 1, mRNA (cDNA clone IMAGE:40033843), complete cds. JD349638 - Sequence 330662 from Patent EP1572962. JD238748 - Sequence 219772 from Patent EP1572962. BC148686 - Synthetic construct Homo sapiens clone IMAGE:100015709, MGC:183158 solute carrier family 13 (sodium/sulfate symporters), member 1 (SLC13A1) mRNA, encodes complete protein. AK314537 - Homo sapiens cDNA, FLJ95359, Homo sapiens solute carrier family 13 (sodium/sulfate symporters), member 1 (SLC13A1), mRNA. BC140317 - Synthetic construct Homo sapiens clone IMAGE:100014354, MGC:173215 solute carrier family 13 (sodium/sulfate symporters), member 1 (SLC13A1) mRNA, encodes complete protein. AB528233 - Synthetic construct DNA, clone: pF1KB7228, Homo sapiens SLC13A1 gene for solute carrier family 13 (sodium/sulfate symporters), member 1, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BZW2 (Reactome details) participates in the following event(s):
R-HSA-433114 NaS1 co-transports sulphate and a sodium ion R-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425471 Bile salt and organic anion SLC transporters R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules