Human Gene SLC13A1 (ENST00000194130.7) from GENCODE V44
  Description: Homo sapiens solute carrier family 13 member 1 (SLC13A1), transcript variant 1, mRNA. (from RefSeq NM_022444)
RefSeq Summary (NM_022444): The protein encoded by this gene is an apical membrane Na(+)-sulfate cotransporter involved in sulfate homeostasis in the kidney. Defects in this gene lead to many pathophysiologic problems. [provided by RefSeq, May 2016].
Gencode Transcript: ENST00000194130.7
Gencode Gene: ENSG00000081800.9
Transcript (Including UTRs)
   Position: hg38 chr7:123,113,531-123,199,969 Size: 86,439 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg38 chr7:123,115,518-123,199,946 Size: 84,429 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:123,113,531-123,199,969)mRNA (may differ from genome)Protein (595 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtOMIM
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S13A1_HUMAN
DESCRIPTION: RecName: Full=Solute carrier family 13 member 1; AltName: Full=Renal sodium/sulfate cotransporter; Short=Na(+)/sulfate cotransporter; Short=hNaSi-1;
FUNCTION: Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in kidney; not detectable in the other tissues tested.
INDUCTION: Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate.
SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.82 RPKM in Small Intestine - Terminal Ileum
Total median expression: 7.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.0023-0.087 Picture PostScript Text
3' UTR -379.301987-0.191 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001898 - Na/sul_symport

Pfam Domains:
PF00939 - Sodium:sulfate symporter transmembrane region

ModBase Predicted Comparative 3D Structure on Q9BZW2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015382 sodium:sulfate symporter activity

Biological Process:
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0008272 sulfate transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902358 sulfate transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF260824 - Homo sapiens renal sodium/sulfate cotransporter mRNA, complete cds.
JD126390 - Sequence 107414 from Patent EP1572962.
AK026413 - Homo sapiens cDNA: FLJ22760 fis, clone KAIA0881.
JD492872 - Sequence 473896 from Patent EP1572962.
JD492950 - Sequence 473974 from Patent EP1572962.
JD047370 - Sequence 28394 from Patent EP1572962.
JD086770 - Sequence 67794 from Patent EP1572962.
JD188455 - Sequence 169479 from Patent EP1572962.
JD195307 - Sequence 176331 from Patent EP1572962.
BC111775 - Homo sapiens solute carrier family 13 (sodium/sulfate symporters), member 1, mRNA (cDNA clone IMAGE:40033843), complete cds.
JD349638 - Sequence 330662 from Patent EP1572962.
JD238748 - Sequence 219772 from Patent EP1572962.
BC148686 - Synthetic construct Homo sapiens clone IMAGE:100015709, MGC:183158 solute carrier family 13 (sodium/sulfate symporters), member 1 (SLC13A1) mRNA, encodes complete protein.
AK314537 - Homo sapiens cDNA, FLJ95359, Homo sapiens solute carrier family 13 (sodium/sulfate symporters), member 1 (SLC13A1), mRNA.
BC140317 - Synthetic construct Homo sapiens clone IMAGE:100014354, MGC:173215 solute carrier family 13 (sodium/sulfate symporters), member 1 (SLC13A1) mRNA, encodes complete protein.
AB528233 - Synthetic construct DNA, clone: pF1KB7228, Homo sapiens SLC13A1 gene for solute carrier family 13 (sodium/sulfate symporters), member 1, without stop codon, in Flexi system.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BZW2 (Reactome details) participates in the following event(s):

R-HSA-433114 NaS1 co-transports sulphate and a sodium ion
R-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425471 Bile salt and organic anion SLC transporters
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000194130.1, ENST00000194130.2, ENST00000194130.3, ENST00000194130.4, ENST00000194130.5, ENST00000194130.6, NAS1, NASI1, NM_022444, Q9BZW2, Q9H5Z0, S13A1_HUMAN, uc003vkm.1, uc003vkm.2, uc003vkm.3, uc003vkm.4, uc003vkm.5
UCSC ID: ENST00000194130.7
RefSeq Accession: NM_022444
Protein: Q9BZW2 (aka S13A1_HUMAN or S131_HUMAN)
CCDS: CCDS5786.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.