Human Gene GIMAP2 (ENST00000223293.10) from GENCODE V44
  Description: Homo sapiens GTPase, IMAP family member 2 (GIMAP2), mRNA. (from RefSeq NM_015660)
RefSeq Summary (NM_015660): This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000223293.10
Gencode Gene: ENSG00000106560.11
Transcript (Including UTRs)
   Position: hg38 chr7:150,685,706-150,693,641 Size: 7,936 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr7:150,687,060-150,693,300 Size: 6,241 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:150,685,706-150,693,641)mRNA (may differ from genome)Protein (337 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GIMA2_HUMAN
DESCRIPTION: RecName: Full=GTPase IMAP family member 2; AltName: Full=Immunity-associated protein 2; Short=hIMAP2;
SUBUNIT: Monomer in the presence of bound GDP and in the absence of bound nucleotide. Homodimer in the presence of bound GTP. Can form linear oligomers.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Note=Detected on the surface of cytoplasmic lipid droplets.
SIMILARITY: Belongs to the IAN GTP-binding protein family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GIMAP2
Diseases sorted by gene-association score: behcet syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.73 RPKM in Spleen
Total median expression: 196.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.8088-0.180 Picture PostScript Text
3' UTR -56.00341-0.164 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006703 - AIG1

Pfam Domains:
PF04548 - AIG1 family

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2XTM - X-ray MuPIT 2XTN - X-ray MuPIT 2XTO - X-ray MuPIT 2XTP - X-ray MuPIT 3P1J - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9UG22
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042802 identical protein binding

Cellular Component:
GO:0005737 cytoplasm
GO:0005811 lipid particle
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ893533 - Synthetic construct Homo sapiens clone ccsbBroadEn_02927 GIMAP2 gene, encodes complete protein.
AK074199 - Homo sapiens cDNA FLJ23619 fis, clone ADSE00761.
BC013934 - Homo sapiens GTPase, IMAP family member 2, mRNA (cDNA clone MGC:24275 IMAGE:3950542), complete cds.
AL110151 - Homo sapiens mRNA; cDNA DKFZp586D0824 (from clone DKFZp586D0824).
BC032345 - Homo sapiens GTPase, IMAP family member 2, mRNA (cDNA clone MGC:40527 IMAGE:5208411), complete cds.
JD174381 - Sequence 155405 from Patent EP1572962.
CU680702 - Synthetic construct Homo sapiens gateway clone IMAGE:100018140 5' read GIMAP2 mRNA.
HQ447229 - Synthetic construct Homo sapiens clone IMAGE:100070532; CCSB007383_01 GTPase, IMAP family member 2 (GIMAP2) gene, encodes complete protein.
JD048144 - Sequence 29168 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000223293.1, ENST00000223293.2, ENST00000223293.3, ENST00000223293.4, ENST00000223293.5, ENST00000223293.6, ENST00000223293.7, ENST00000223293.8, ENST00000223293.9, GIMA2_HUMAN, IMAP2, NM_015660, Q96L25, Q9UG22, uc003who.1, uc003who.2, uc003who.3, uc003who.4, uc003who.5
UCSC ID: ENST00000223293.10
RefSeq Accession: NM_015660
Protein: Q9UG22 (aka GIMA2_HUMAN or IMP2_HUMAN)
CCDS: CCDS5905.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.