Human Gene INTS10 (ENST00000397977.8) from GENCODE V44
Description: Homo sapiens integrator complex subunit 10 (INTS10), transcript variant 27, non-coding RNA. (from RefSeq NR_148458) RefSeq Summary (NM_018142): INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000397977.8 Gencode Gene: ENSG00000104613.12 Transcript (Including UTRs) Position: hg38 chr8:19,817,416-19,852,067 Size: 34,652 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr8:19,817,538-19,851,805 Size: 34,268 Coding Exon Count: 17
ID:INT10_HUMAN DESCRIPTION: RecName: Full=Integrator complex subunit 10; Short=Int10; FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. SUBUNIT: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with POLR2A. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Integrator subunit 10 family. SEQUENCE CAUTION: Sequence=BAA91687.1; Type=Frameshift; Positions=90; Sequence=CAG33543.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NVR2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
