Human Gene DUSP4 (ENST00000240100.7) from GENCODE V44
Description: Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 1, mRNA. (from RefSeq NM_001394) RefSeq Summary (NM_001394): The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000240100.7 Gencode Gene: ENSG00000120875.9 Transcript (Including UTRs) Position: hg38 chr8:29,333,064-29,350,684 Size: 17,621 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr8:29,337,026-29,350,278 Size: 13,253 Coding Exon Count: 4
ID:DUS4_HUMAN DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 4; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Dual specificity protein phosphatase hVH2; AltName: Full=Mitogen-activated protein kinase phosphatase 2; Short=MAP kinase phosphatase 2; Short=MKP-2; FUNCTION: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. SUBUNIT: Hollow spherical complex composed of 24 subunits with pseudooctahedral symmetry, has a tetramer as the basic unit. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. SIMILARITY: Contains 1 rhodanese domain. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13115
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
