Human Gene PPP2CB (ENST00000221138.9) from GENCODE V41
  Description: Homo sapiens protein phosphatase 2 catalytic subunit beta (PPP2CB), mRNA. (from RefSeq NM_001009552)
RefSeq Summary (NM_001009552): This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010].
Gencode Transcript: ENST00000221138.9
Gencode Gene: ENSG00000104695.13
Transcript (Including UTRs)
   Position: hg38 chr8:30,785,616-30,812,818 Size: 27,203 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr8:30,786,235-30,812,421 Size: 26,187 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2022-05-14 09:57:26

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:30,785,616-30,812,818)mRNA (may differ from genome)Protein (309 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; Short=PP2A-beta; EC=;
FUNCTION: PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
COFACTOR: Binds 1 manganese ion per subunit (By similarity).
SUBUNIT: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGOL1, most probably through regulatory B56 subunits.
INTERACTION: P78318:IGBP1; NbExp=3; IntAct=EBI-1044367, EBI-1055954;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
PTM: Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. Demethylated by PME1 (in vitro).
PTM: Phosphorylation of either threonine (by autophosphorylation- activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
SIMILARITY: Belongs to the PPP phosphatase family. PP-1 subfamily.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 74.92 RPKM in Brain - Amygdala
Total median expression: 2078.79 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -233.60397-0.588 Picture PostScript Text
3' UTR -122.30619-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004843 - Metallo_PEstase_dom
IPR006186 - Ser/Thr-sp_prot-phosphatase

Pfam Domains:
PF00149 - Calcineurin-like phosphoesterase

ModBase Predicted Comparative 3D Structure on P62714
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
Protein SequenceProtein SequenceProtein Sequence  Protein Sequence
AlignmentAlignmentAlignment  Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006470 protein dephosphorylation
GO:0008637 apoptotic mitochondrial changes
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0034976 response to endoplasmic reticulum stress
GO:0035970 peptidyl-threonine dephosphorylation
GO:0042542 response to hydrogen peroxide
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0046677 response to antibiotic
GO:0070262 peptidyl-serine dephosphorylation
GO:1904528 positive regulation of microtubule binding

Cellular Component:
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton

-  Descriptions from all associated GenBank mRNAs
  LF384356 - JP 2014500723-A/191859: Polycomb-Associated Non-Coding RNAs.
MA619933 - JP 2018138019-A/191859: Polycomb-Associated Non-Coding RNAs.
BC012022 - Homo sapiens protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform, mRNA (cDNA clone MGC:21354 IMAGE:4454972), complete cds.
AK091875 - Homo sapiens cDNA FLJ34556 fis, clone KIDNE2000867, highly similar to Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC
J03805 - Human phosphatase 2A mRNA, partial cds.
X12656 - Human mRNA for protein phosphatase 2A (beta-type).
HM005459 - Homo sapiens clone HTL-T-146 testicular tissue protein Li 146 mRNA, complete cds.
CR541747 - Homo sapiens full open reading frame cDNA clone RZPDo834F0729D for gene PPP2CB, protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; complete cds, incl. stopcodon.
AF444006 - Homo sapiens protein phosphatase type 2A catalytic subunit mRNA, complete cds.
BT019526 - Homo sapiens protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform mRNA, complete cds.
KJ891868 - Synthetic construct Homo sapiens clone ccsbBroadEn_01262 PPP2CB gene, encodes complete protein.
AB590734 - Synthetic construct DNA, clone: pFN21AE1794, Homo sapiens PPP2CB gene for protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform, without stop codon, in Flexi system.
CU680166 - Synthetic construct Homo sapiens gateway clone IMAGE:100017006 5' read PPP2CB mRNA.
JD184382 - Sequence 165406 from Patent EP1572962.
JD502638 - Sequence 483662 from Patent EP1572962.
JD196792 - Sequence 177816 from Patent EP1572962.
JD019890 - Sequence 914 from Patent EP1572962.
JD033122 - Sequence 14146 from Patent EP1572962.
LF371920 - JP 2014500723-A/179423: Polycomb-Associated Non-Coding RNAs.
MA607497 - JP 2018138019-A/179423: Polycomb-Associated Non-Coding RNAs.
DQ581665 - Homo sapiens piRNA piR-49777, complete sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04114 - Oocyte meiosis
hsa04310 - Wnt signaling pathway
hsa04350 - TGF-beta signaling pathway
hsa04530 - Tight junction
hsa04730 - Long-term depression
hsa05142 - Chagas disease

Reactome (by CSHL, EBI, and GO)

Protein P62714 (Reactome details) participates in the following event(s):

R-HSA-1295622 SPRY2 binds CBL
R-HSA-163769 Activation of PP2A by Xylulose-5-phosphate
R-HSA-195251 Assembly of the destruction complex
R-HSA-389532 PP2A binds CTLA4 homodimer
R-HSA-432143 PECAM-1 binds PP2A
R-HSA-8857925 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
R-HSA-201685 Beta-catenin is released from the destruction complex
R-HSA-388833 Phosphorylation of CTLA-4
R-HSA-6811454 MAPKs phosphorylate PP2A
R-HSA-6811472 IER3 recruits MAPKs to PP2A-B56-beta,gamma
R-HSA-8856945 PP2A methylation by LCMT1
R-HSA-8856951 PP2A demethylation by PPME1
R-HSA-2430552 p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D
R-HSA-6792871 CCNG1 recruits PP2A-PPP2R5C to MDM2
R-HSA-6792863 PP2A-PP2R5C dephosphorylates MDM2
R-HSA-934559 SPRY2 is phosphorylated by phosphorylated MNK1
R-HSA-1295609 SRC phosphorylates SPRY2 on Y55 and Y227
R-HSA-1295599 SPRY2 translocates to the plasma membrane
R-HSA-1295613 SPRY2 binds GRB2
R-HSA-1549564 PPTN11 dephosphorylates SPRY2
R-HSA-1295632 PPA2A dephosphorylates SPRY2
R-HSA-163689 Dephosphorylation of pChREBP (Ser 196) by PP2A
R-HSA-163750 Dephosphorylation of phosphoPFKFB1 by PP2A complex
R-HSA-201790 DARPP-32 is dephosphorylated on Thr75 by PP2A
R-HSA-5229343 AXIN is phosphorylated in the destruction complex
R-HSA-195280 Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
R-HSA-195275 Phosphorylation of APC component of the destruction complex
R-HSA-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
R-HSA-141409 Mad1 binds kinetochore
R-HSA-375302 Kinetochore capture of astral microtubules
R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores
R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
R-HSA-388809 CTLA-4 binds B7-1/B7-2
R-HSA-195304 Association of beta-catenin with the destruction complex
R-HSA-390329 Dephosphorylation of AKT by PP2A
R-HSA-5672957 PP2A dephosphorylates KSR1
R-HSA-5672961 PP2A dephosphorylates inactive RAFs
R-HSA-5675431 PP2A dephosphorylates RAF1
R-HSA-6811504 AKT1 dephosphorylation by PP2A-B56-beta,gamma
R-HSA-163688 Dephosphorylation of pChREBP (Thr 666) by PP2A
R-HSA-164056 Dephosphorylation of pChREBP (Ser 568) by PP2A
R-HSA-199959 ERKs are inactivated by protein phosphatase 2A
R-HSA-113503 PP2A mediated localization of RB1 protein in chromatin
R-HSA-1363274 Dephosphorylation of p107 (RBL1) by PP2A
R-HSA-1363276 Dephosphorylation of p130 (RBL2) by PP2A
R-HSA-4088141 PP2A-PPP2R2A dephosphorylates FOXM1
R-HSA-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex
R-HSA-141439 Release of activated MAD2 from kinetochores
R-HSA-2467811 Separation of sister chromatids
R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin
R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores
R-HSA-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
R-HSA-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha
R-HSA-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
R-HSA-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1
R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin
R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres
R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-163685 Energy Metabolism
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-432142 Platelet sensitization by LDL
R-HSA-5467337 APC truncation mutants have impaired AXIN binding
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-2465910 MASTL Facilitates Mitotic Progression
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-1430728 Metabolism
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors
R-HSA-70171 Glycolysis
R-HSA-180024 DARPP-32 events
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-68877 Mitotic Prometaphase
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-195721 Signaling by WNT
R-HSA-388841 Costimulation by the CD28 family
R-HSA-418346 Platelet homeostasis
R-HSA-4839744 truncated APC mutants destabilize the destruction complex
R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling
R-HSA-4839748 AMER1 mutants destabilize the destruction complex
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-5673000 RAF activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-198753 ERK/MAPK targets
R-HSA-202670 ERKs are inactivated
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-HSA-69275 G2/M Transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-68875 Mitotic Prophase
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-70326 Glucose metabolism
R-HSA-111885 Opioid Signalling
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-141424 Amplification of signal from the kinetochores
R-HSA-68886 M Phase
R-HSA-195258 RHO GTPase Effectors
R-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-162582 Signal Transduction
R-HSA-1280218 Adaptive Immune System
R-HSA-109582 Hemostasis
R-HSA-4791275 Signaling by WNT in cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-113510 E2F mediated regulation of DNA replication
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69236 G1 Phase
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-190236 Signaling by FGFR
R-HSA-71387 Metabolism of carbohydrates
R-HSA-418594 G alpha (i) signalling events
R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
R-HSA-68882 Mitotic Anaphase
R-HSA-69618 Mitotic Spindle Checkpoint
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-194315 Signaling by Rho GTPases
R-HSA-168256 Immune System
R-HSA-5663202 Diseases of signal transduction
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-450294 MAP kinase activation
R-HSA-69206 G1/S Transition
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-388396 GPCR downstream signalling
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-5683057 MAPK family signaling cascades
R-HSA-166520 Signaling by NTRKs
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-448424 Interleukin-17 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-212436 Generic Transcription Pathway
R-HSA-372790 Signaling by GPCR
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-449147 Signaling by Interleukins
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168249 Innate Immune System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: D3DSV4, ENST00000221138.1, ENST00000221138.2, ENST00000221138.3, ENST00000221138.4, ENST00000221138.5, ENST00000221138.6, ENST00000221138.7, ENST00000221138.8, NM_001009552, P11082, P62714, PP2AB_HUMAN, Q6FHK5, uc003xik.1, uc003xik.2, uc003xik.3, uc003xik.4, uc003xik.5
UCSC ID: ENST00000221138.9
RefSeq Accession: NM_001009552
Protein: P62714 (aka PP2AB_HUMAN)
CCDS: CCDS6079.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.