Human Gene POMK (ENST00000331373.10) from GENCODE V44
Description: Homo sapiens protein O-mannose kinase (POMK), transcript variant 1, mRNA. (from RefSeq NM_032237) RefSeq Summary (NM_032237): This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]. Gencode Transcript: ENST00000331373.10 Gencode Gene: ENSG00000185900.11 Transcript (Including UTRs) Position: hg38 chr8:43,093,515-43,123,434 Size: 29,920 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr8:43,103,549-43,122,877 Size: 19,329 Coding Exon Count: 2
ID:SG196_HUMAN DESCRIPTION: RecName: Full=Protein kinase-like protein SgK196; AltName: Full=Sugen kinase 196; SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). DOMAIN: The protein kinase domain is predicted to be catalytically inactive. SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H5K3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
