Human Gene TRIM55 (ENST00000315962.9) Description and Page Index
  Description: Homo sapiens tripartite motif containing 55 (TRIM55), transcript variant 1, mRNA. (from RefSeq NM_184085)
RefSeq Summary (NM_184085): The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000315962.9
Gencode Gene: ENSG00000147573.17
Transcript (Including UTRs)
   Position: hg38 chr8:66,127,129-66,175,485 Size: 48,357 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr8:66,127,269-66,174,593 Size: 47,325 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:66,127,129-66,175,485)mRNA (may differ from genome)Protein (548 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TRI55_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 55; AltName: Full=Muscle-specific RING finger protein 2; Short=MuRF-2; Short=MuRF2; AltName: Full=RING finger protein 29;
FUNCTION: May regulate gene expression and protein turnover in muscle cells (By similarity).
SUBUNIT: Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54.
INTERACTION: Self; NbExp=2; IntAct=EBI-2341179, EBI-2341179;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity).
TISSUE SPECIFICITY: Highly expressed in muscle. Low-level expression in liver.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 COS domain.
SIMILARITY: Contains 1 RING-type zinc finger.
CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator.
SEQUENCE CAUTION: Sequence=AAP35876.1; Type=Erroneous initiation; Sequence=CAC32839.1; Type=Erroneous initiation; Sequence=CAC32840.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.60 RPKM in Heart - Atrial Appendage
Total median expression: 66.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.00140-0.271 Picture PostScript Text
3' UTR -212.00892-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017903 - COS_domain
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00643 - B-box zinc finger

ModBase Predicted Comparative 3D Structure on Q9BYV6
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0007165 signal transduction

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule


-  Descriptions from all associated GenBank mRNAs
  AK091310 - Homo sapiens cDNA FLJ33991 fis, clone DFNES2007332, highly similar to Homo sapiens tripartite motif-containing 55 (TRIM55), transcript variant 3, mRNA.
AX746908 - Sequence 433 from Patent EP1308459.
AJ431704 - Homo sapiens RNF29 gene for RING finger protein 29, alternative C-terminal isoform.
AJ243488 - Homo sapiens RNF29 gene for RING finger protein 29, 50kDa isoform.
AJ243489 - Homo sapiens RNF29 gene for RING finger protein 29, 60kDa isoform.
AJ277493 - Homo sapiens RNF29 gene for RING finger protein 29, 27 kDa isoform.
BC007750 - Homo sapiens tripartite motif-containing 55, mRNA (cDNA clone MGC:12836 IMAGE:4110783), complete cds.
AJ291712 - Homo sapiens mRNA for RNF29 gene for ring finger protein 29.
JD510284 - Sequence 491308 from Patent EP1572962.
JD189698 - Sequence 170722 from Patent EP1572962.
AK091728 - Homo sapiens cDNA FLJ34409 fis, clone HEART2001931, highly similar to Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2).
AX747148 - Sequence 673 from Patent EP1308459.
CU675793 - Synthetic construct Homo sapiens gateway clone IMAGE:100019470 5' read TRIM55 mRNA.
KJ895019 - Synthetic construct Homo sapiens clone ccsbBroadEn_04413 TRIM55 gene, encodes complete protein.
BT007212 - Homo sapiens ring finger protein 29 mRNA, complete cds.
JD113317 - Sequence 94341 from Patent EP1572962.
JD153415 - Sequence 134439 from Patent EP1572962.
JD527785 - Sequence 508809 from Patent EP1572962.
JD531601 - Sequence 512625 from Patent EP1572962.
JD494890 - Sequence 475914 from Patent EP1572962.
JD302677 - Sequence 283701 from Patent EP1572962.
JD090019 - Sequence 71043 from Patent EP1572962.
JD521844 - Sequence 502868 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KRC0, B3KRJ3, MURF2, NM_184085, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6, RNF29, TRI55_HUMAN, uc003xvv.1, uc003xvv.2, uc003xvv.3, uc003xvv.4, uc003xvv.5
UCSC ID: uc003xvv.5
RefSeq Accession: NM_184085
Protein: Q9BYV6 (aka TRI55_HUMAN)
CCDS: CCDS6184.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.