Human Gene TRIM55 (ENST00000315962.9) Description and Page Index
Description: Homo sapiens tripartite motif containing 55 (TRIM55), transcript variant 1, mRNA. (from RefSeq NM_184085) RefSeq Summary (NM_184085): The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000315962.9 Gencode Gene: ENSG00000147573.17 Transcript (Including UTRs) Position: hg38 chr8:66,127,129-66,175,485 Size: 48,357 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr8:66,127,269-66,174,593 Size: 47,325 Coding Exon Count: 10
ID:TRI55_HUMAN DESCRIPTION: RecName: Full=Tripartite motif-containing protein 55; AltName: Full=Muscle-specific RING finger protein 2; Short=MuRF-2; Short=MuRF2; AltName: Full=RING finger protein 29; FUNCTION: May regulate gene expression and protein turnover in muscle cells (By similarity). SUBUNIT: Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54. INTERACTION: Self; NbExp=2; IntAct=EBI-2341179, EBI-2341179; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity). TISSUE SPECIFICITY: Highly expressed in muscle. Low-level expression in liver. SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 COS domain. SIMILARITY: Contains 1 RING-type zinc finger. CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator. SEQUENCE CAUTION: Sequence=AAP35876.1; Type=Erroneous initiation; Sequence=CAC32839.1; Type=Erroneous initiation; Sequence=CAC32840.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BYV6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK091310 - Homo sapiens cDNA FLJ33991 fis, clone DFNES2007332, highly similar to Homo sapiens tripartite motif-containing 55 (TRIM55), transcript variant 3, mRNA. AX746908 - Sequence 433 from Patent EP1308459. AJ431704 - Homo sapiens RNF29 gene for RING finger protein 29, alternative C-terminal isoform. AJ243488 - Homo sapiens RNF29 gene for RING finger protein 29, 50kDa isoform. AJ243489 - Homo sapiens RNF29 gene for RING finger protein 29, 60kDa isoform. AJ277493 - Homo sapiens RNF29 gene for RING finger protein 29, 27 kDa isoform. BC007750 - Homo sapiens tripartite motif-containing 55, mRNA (cDNA clone MGC:12836 IMAGE:4110783), complete cds. AJ291712 - Homo sapiens mRNA for RNF29 gene for ring finger protein 29. JD510284 - Sequence 491308 from Patent EP1572962. JD189698 - Sequence 170722 from Patent EP1572962. AK091728 - Homo sapiens cDNA FLJ34409 fis, clone HEART2001931, highly similar to Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2). AX747148 - Sequence 673 from Patent EP1308459. CU675793 - Synthetic construct Homo sapiens gateway clone IMAGE:100019470 5' read TRIM55 mRNA. KJ895019 - Synthetic construct Homo sapiens clone ccsbBroadEn_04413 TRIM55 gene, encodes complete protein. BT007212 - Homo sapiens ring finger protein 29 mRNA, complete cds. JD113317 - Sequence 94341 from Patent EP1572962. JD153415 - Sequence 134439 from Patent EP1572962. JD527785 - Sequence 508809 from Patent EP1572962. JD531601 - Sequence 512625 from Patent EP1572962. JD494890 - Sequence 475914 from Patent EP1572962. JD302677 - Sequence 283701 from Patent EP1572962. JD090019 - Sequence 71043 from Patent EP1572962. JD521844 - Sequence 502868 from Patent EP1572962.