Human Gene TRIM55 (ENST00000315962.9) Description and Page Index
  Description: Homo sapiens tripartite motif containing 55 (TRIM55), transcript variant 1, mRNA. (from RefSeq NM_184085)
RefSeq Summary (NM_184085): The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000315962.9
Gencode Gene: ENSG00000147573.17
Transcript (Including UTRs)
   Position: hg38 chr8:66,127,129-66,175,485 Size: 48,357 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr8:66,127,269-66,174,593 Size: 47,325 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:66,127,129-66,175,485)mRNA (may differ from genome)Protein (548 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 55; AltName: Full=Muscle-specific RING finger protein 2; Short=MuRF-2; Short=MuRF2; AltName: Full=RING finger protein 29;
FUNCTION: May regulate gene expression and protein turnover in muscle cells (By similarity).
SUBUNIT: Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54.
INTERACTION: Self; NbExp=2; IntAct=EBI-2341179, EBI-2341179;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity).
TISSUE SPECIFICITY: Highly expressed in muscle. Low-level expression in liver.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 COS domain.
SIMILARITY: Contains 1 RING-type zinc finger.
CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator.
SEQUENCE CAUTION: Sequence=AAP35876.1; Type=Erroneous initiation; Sequence=CAC32839.1; Type=Erroneous initiation; Sequence=CAC32840.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.60 RPKM in Heart - Atrial Appendage
Total median expression: 66.49 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.00140-0.271 Picture PostScript Text
3' UTR -212.00892-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017903 - COS_domain
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00643 - B-box zinc finger

ModBase Predicted Comparative 3D Structure on Q9BYV6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0007165 signal transduction

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule

-  Descriptions from all associated GenBank mRNAs
  AK091310 - Homo sapiens cDNA FLJ33991 fis, clone DFNES2007332, highly similar to Homo sapiens tripartite motif-containing 55 (TRIM55), transcript variant 3, mRNA.
AX746908 - Sequence 433 from Patent EP1308459.
AJ431704 - Homo sapiens RNF29 gene for RING finger protein 29, alternative C-terminal isoform.
AJ243488 - Homo sapiens RNF29 gene for RING finger protein 29, 50kDa isoform.
AJ243489 - Homo sapiens RNF29 gene for RING finger protein 29, 60kDa isoform.
AJ277493 - Homo sapiens RNF29 gene for RING finger protein 29, 27 kDa isoform.
BC007750 - Homo sapiens tripartite motif-containing 55, mRNA (cDNA clone MGC:12836 IMAGE:4110783), complete cds.
AJ291712 - Homo sapiens mRNA for RNF29 gene for ring finger protein 29.
JD510284 - Sequence 491308 from Patent EP1572962.
JD189698 - Sequence 170722 from Patent EP1572962.
AK091728 - Homo sapiens cDNA FLJ34409 fis, clone HEART2001931, highly similar to Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2).
AX747148 - Sequence 673 from Patent EP1308459.
CU675793 - Synthetic construct Homo sapiens gateway clone IMAGE:100019470 5' read TRIM55 mRNA.
KJ895019 - Synthetic construct Homo sapiens clone ccsbBroadEn_04413 TRIM55 gene, encodes complete protein.
BT007212 - Homo sapiens ring finger protein 29 mRNA, complete cds.
JD113317 - Sequence 94341 from Patent EP1572962.
JD153415 - Sequence 134439 from Patent EP1572962.
JD527785 - Sequence 508809 from Patent EP1572962.
JD531601 - Sequence 512625 from Patent EP1572962.
JD494890 - Sequence 475914 from Patent EP1572962.
JD302677 - Sequence 283701 from Patent EP1572962.
JD090019 - Sequence 71043 from Patent EP1572962.
JD521844 - Sequence 502868 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KRC0, B3KRJ3, MURF2, NM_184085, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6, RNF29, TRI55_HUMAN, uc003xvv.1, uc003xvv.2, uc003xvv.3, uc003xvv.4, uc003xvv.5
UCSC ID: uc003xvv.5
RefSeq Accession: NM_184085
Protein: Q9BYV6 (aka TRI55_HUMAN)
CCDS: CCDS6184.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.