Human Gene FABP5 (ENST00000297258.11) from GENCODE V44
Description: Homo sapiens fatty acid binding protein 5 (FABP5), mRNA. (from RefSeq NM_001444) RefSeq Summary (NM_001444): This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]. Gencode Transcript: ENST00000297258.11 Gencode Gene: ENSG00000164687.11 Transcript (Including UTRs) Position: hg38 chr8:81,280,536-81,284,775 Size: 4,240 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr8:81,280,596-81,284,567 Size: 3,972 Coding Exon Count: 4
ID:FABP5_HUMAN DESCRIPTION: RecName: Full=Fatty acid-binding protein, epidermal; AltName: Full=Epidermal-type fatty acid-binding protein; Short=E-FABP; AltName: Full=Fatty acid-binding protein 5; AltName: Full=Psoriasis-associated fatty acid-binding protein homolog; Short=PA-FABP; FUNCTION: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Keratinocytes; highly expressed in psoriatic skin. DOMAIN: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01469
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006006 glucose metabolic process GO:0006629 lipid metabolic process GO:0006656 phosphatidylcholine biosynthetic process GO:0008544 epidermis development GO:0010829 negative regulation of glucose transport GO:0019433 triglyceride catabolic process GO:0042593 glucose homeostasis GO:0043312 neutrophil degranulation