Human Gene EIF3H (ENST00000521861.6) from GENCODE V44
  Description: Homo sapiens eukaryotic translation initiation factor 3 subunit H (EIF3H), mRNA. (from RefSeq NM_003756)
Gencode Transcript: ENST00000521861.6
Gencode Gene: ENSG00000147677.12
Transcript (Including UTRs)
   Position: hg38 chr8:116,642,130-116,755,823 Size: 113,694 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr8:116,645,006-116,755,797 Size: 110,792 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:116,642,130-116,755,823)mRNA (may differ from genome)Protein (352 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EIF3H
Diseases sorted by gene-association score: trichorhinophalangeal syndrome, type i (8), trichorhinophalangeal syndrome, type ii (7), prostate cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 87.69 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1608.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.8026-0.108 Picture PostScript Text
3' UTR -729.012876-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000555 - JAB1_Mov34_MPN_PAD1

Pfam Domains:
PF01398 - JAB1/Mov34/MPN/PAD-1 ubiquitin protease

ModBase Predicted Comparative 3D Structure on Q6IB98
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI EnsemblEnsembl  
Protein Sequence Protein SequenceProtein Sequence  
Alignment AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003743 translation initiation factor activity
GO:0005515 protein binding

Biological Process:
GO:0001732 formation of cytoplasmic translation initiation complex
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation

Cellular Component:
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m


-  Descriptions from all associated GenBank mRNAs
  BC000386 - Homo sapiens eukaryotic translation initiation factor 3, subunit H, mRNA (cDNA clone MGC:8431 IMAGE:2821133), complete cds.
BC090880 - Homo sapiens eukaryotic translation initiation factor 3, subunit H, mRNA (cDNA clone MGC:102958 IMAGE:30367209), complete cds.
AK222520 - Homo sapiens mRNA for eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa variant, clone: adSE01270.
AK093128 - Homo sapiens cDNA FLJ35809 fis, clone TESTI2006016, highly similar to Eukaryotic translation initiation factor 3 subunit 3.
U54559 - Homo sapiens translation initiation factor eIF3 p40 subunit mRNA, complete cds.
AK222620 - Homo sapiens mRNA for eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa variant, clone: CBL00213.
CR456906 - Homo sapiens full open reading frame cDNA clone RZPDo834F0211D for gene EIF3S3, eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa; complete cds, incl. stopcodon.
BT019594 - Homo sapiens eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa mRNA, complete cds.
KJ892591 - Synthetic construct Homo sapiens clone ccsbBroadEn_01985 EIF3H gene, encodes complete protein.
CU674186 - Synthetic construct Homo sapiens gateway clone IMAGE:100018172 5' read EIF3H mRNA.
JD352599 - Sequence 333623 from Patent EP1572962.
AK296162 - Homo sapiens cDNA FLJ57508 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 3.

-  Other Names for This Gene
  Alternate Gene Symbols: EIF3S3, ENST00000521861.1, ENST00000521861.2, ENST00000521861.3, ENST00000521861.4, ENST00000521861.5, hCG_20900, NM_003756, Q6IB98, Q6IB98_HUMAN, uc003yoa.1, uc003yoa.2, uc003yoa.3, uc003yoa.4, uc003yoa.5
UCSC ID: ENST00000521861.6
RefSeq Accession: NM_003756
Protein: Q6IB98 CCDS: CCDS6319.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.