Human Gene TBC1D31 (ENST00000287380.6) from GENCODE V44
  Description: Homo sapiens TBC1 domain family member 31 (TBC1D31), transcript variant 1, mRNA. (from RefSeq NM_145647)
Gencode Transcript: ENST00000287380.6
Gencode Gene: ENSG00000156787.17
Transcript (Including UTRs)
   Position: hg38 chr8:123,072,707-123,152,153 Size: 79,447 Total Exon Count: 22 Strand: +
Coding Region
   Position: hg38 chr8:123,072,770-123,151,939 Size: 79,170 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:123,072,707-123,152,153)mRNA (may differ from genome)Protein (1066 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HPRDLynxMalacardsMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: WDR67_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 67;
SIMILARITY: Contains 1 Rab-GAP TBC domain.
SIMILARITY: Contains 5 WD repeats.
SEQUENCE CAUTION: Sequence=AAH27237.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.80 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 57.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.9063-0.475 Picture PostScript Text
3' UTR -38.80214-0.181 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000195 - Rab-GTPase-TBC_dom
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00566 - Rab-GTPase-TBC domain
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on Q96DN5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005813 centrosome


-  Descriptions from all associated GenBank mRNAs
  AK056434 - Homo sapiens cDNA FLJ31872 fis, clone NT2RP7002376, weakly similar to M PROTEIN, SEROTYPE 2.1 PRECURSOR.
BC143525 - Homo sapiens WD repeat domain 67, mRNA (cDNA clone MGC:177051 IMAGE:9052034), complete cds.
BC101724 - Homo sapiens WD repeat domain 67, mRNA (cDNA clone MGC:126773 IMAGE:8069230), complete cds.
BC111954 - Homo sapiens WD repeat domain 67, mRNA (cDNA clone MGC:138159 IMAGE:8327422), complete cds.
BC143523 - Homo sapiens cDNA clone IMAGE:9052032.
BC105800 - Homo sapiens WD repeat domain 67, mRNA (cDNA clone IMAGE:4251672), complete cds.
AK094612 - Homo sapiens cDNA FLJ37293 fis, clone BRAMY2014813.
JD361646 - Sequence 342670 from Patent EP1572962.
JD456096 - Sequence 437120 from Patent EP1572962.
AK092041 - Homo sapiens cDNA FLJ34722 fis, A-MESAN2005808.
BC026969 - Homo sapiens WD repeat domain 67, mRNA (cDNA clone IMAGE:5116073), partial cds.
AK025686 - Homo sapiens cDNA: FLJ22033 fis, clone HEP08810, highly similar to HSU43374 Human normal keratinocyte mRNA.
BC027237 - Homo sapiens WD repeat domain 67, mRNA (cDNA clone IMAGE:4513891), complete cds.
KJ904952 - Synthetic construct Homo sapiens clone ccsbBroadEn_14346 WDR67 gene, encodes complete protein.
U43374 - Human normal keratinocyte mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZL19, ENST00000287380.1, ENST00000287380.2, ENST00000287380.3, ENST00000287380.4, ENST00000287380.5, NM_145647, Q2M2J9, Q3MIR6, Q8TBP9, Q96DN5, uc003ypp.1, uc003ypp.2, uc003ypp.3, uc003ypp.4, WDR67, WDR67_HUMAN
UCSC ID: ENST00000287380.6
RefSeq Accession: NM_145647
Protein: Q96DN5 (aka WDR67_HUMAN)
CCDS: CCDS6338.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.