Human Gene CNTLN (ENST00000380641.4) from GENCODE V44
  Description: Homo sapiens centlein (CNTLN), transcript variant 2, mRNA. (from RefSeq NM_001114395)
Gencode Transcript: ENST00000380641.4
Gencode Gene: ENSG00000044459.15
Transcript (Including UTRs)
   Position: hg38 chr9:17,135,040-17,302,051 Size: 167,012 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr9:17,135,066-17,298,382 Size: 163,317 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:17,135,040-17,302,051)mRNA (may differ from genome)Protein (391 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CNTLN_HUMAN
DESCRIPTION: RecName: Full=Centlein; AltName: Full=Centrosomal protein;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Colocalizes with gamma-tubulin during interphase and mitosis. Appears to associated with the mother centriole during G1 phase and with daughter centrioles towards G1/S phase (By similarity).
SEQUENCE CAUTION: Sequence=BAA91052.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB13850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CNTLN
Diseases sorted by gene-association score: microcephalic osteodysplastic primordial dwarfism, type ii (8), meesmann corneal dystrophy (6), seckel syndrome (4), growth hormone deficiency, isolated, type ia (4), bardet-biedl syndrome 2 (4), meckel syndrome 1 (1), joubert syndrome 1 (1), leber congenital amaurosis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.91 RPKM in Ovary
Total median expression: 58.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.8026-0.069 Picture PostScript Text
3' UTR -872.603669-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003661 - Sig_transdc_His_kin_sub1_dim/P

ModBase Predicted Comparative 3D Structure on Q9NXG0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030674 protein binding, bridging

Biological Process:
GO:0010457 centriole-centriole cohesion
GO:0033365 protein localization to organelle

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK308837 - Homo sapiens cDNA, FLJ98878.
BX647069 - Homo sapiens mRNA; cDNA DKFZp686K1269 (from clone DKFZp686K1269).
AK098502 - Homo sapiens cDNA FLJ25636 fis, clone STM04338.
BC156251 - Synthetic construct Homo sapiens clone IMAGE:100061645, MGC:190063 centlein, centrosomal protein (CNTLN) mRNA, encodes complete protein.
AK000283 - Homo sapiens cDNA FLJ20276 fis, clone HEP02437.
AK303973 - Homo sapiens cDNA FLJ61043 complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A5Z2X6, C9orf101, C9orf39, CNTLN_HUMAN, ENST00000380641.1, ENST00000380641.2, ENST00000380641.3, NM_001114395, Q5VYJ0, Q8N1G9, Q9HAJ5, Q9NXG0, uc003zmx.1, uc003zmx.2, uc003zmx.3, uc003zmx.4, uc003zmx.5, uc003zmx.6
UCSC ID: ENST00000380641.4
RefSeq Accession: NM_001114395
Protein: Q9NXG0 (aka CNTLN_HUMAN)
CCDS: CCDS47953.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.