Human Gene SPAG8 (ENST00000340291.6) from GENCODE V44
Description: Homo sapiens sperm associated antigen 8 (SPAG8), transcript variant 2, mRNA. (from RefSeq NM_172312) RefSeq Summary (NM_172312): The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2012]. Gencode Transcript: ENST00000340291.6 Gencode Gene: ENSG00000137098.14 Transcript (Including UTRs) Position: hg38 chr9:35,808,045-35,812,272 Size: 4,228 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr9:35,808,173-35,812,147 Size: 3,975 Coding Exon Count: 8
ID:SPAG8_HUMAN DESCRIPTION: RecName: Full=Sperm-associated antigen 8; AltName: Full=HSD-1; AltName: Full=Sperm membrane protein 1; Short=SMP-1; AltName: Full=Sperm membrane protein BS-84; FUNCTION: May play a role in fertility and microtubule formation through interaction with RANBP9. SUBUNIT: Interacts with RANBP9. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Acrosomal region of the head of mature sperm cells. TISSUE SPECIFICITY: Expressed in testis (germ cells), but not in liver, kidney, prostate and small intestine. SEQUENCE CAUTION: Sequence=AAB46833.1; Type=Erroneous termination; Positions=427; Note=Translated as stop;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99932
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.