Human Gene PIP5K1B (ENST00000265382.8) from GENCODE V44
  Description: Homo sapiens phosphatidylinositol-4-phosphate 5-kinase type 1 beta (PIP5K1B), transcript variant 2, mRNA. (from RefSeq NM_003558)
Gencode Transcript: ENST00000265382.8
Gencode Gene: ENSG00000107242.20
Transcript (Including UTRs)
   Position: hg38 chr9:68,705,240-69,009,176 Size: 303,937 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg38 chr9:68,822,615-69,008,449 Size: 185,835 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:68,705,240-69,009,176)mRNA (may differ from genome)Protein (540 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGImyGene2
neXtProtOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PI51B_HUMAN
DESCRIPTION: RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Short=PIP5K1-beta; Short=PtdIns(4)P-5-kinase 1 beta; EC=2.7.1.68; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I beta; Short=PIP5KIbeta; AltName: Full=Protein STM-7; AltName: Full=Type I phosphatidylinositol 4-phosphate 5-kinase beta;
FUNCTION: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).
CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
SUBUNIT: Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1 (By similarity).
SUBCELLULAR LOCATION: Endomembrane system (By similarity). Note=Associated with membranes (By similarity).
TISSUE SPECIFICITY: Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.
SIMILARITY: Contains 1 PIPK domain.
CAUTION: There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

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Click here to open Exonprimer with this transcript

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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.22 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 164.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -324.60765-0.424 Picture PostScript Text
3' UTR -154.50727-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023610 - PInositol-4-P-5-kinase
IPR002498 - PInositol-4-P-5-kinase_core
IPR016034 - PInositol-4P-5-kinase_core_sub

Pfam Domains:
PF01504 - Phosphatidylinositol-4-phosphate 5-Kinase

ModBase Predicted Comparative 3D Structure on O14986
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016740 transferase activity
GO:0052810 1-phosphatidylinositol-5-kinase activity
GO:0052811 1-phosphatidylinositol-3-phosphate 4-kinase activity
GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity

Biological Process:
GO:0006661 phosphatidylinositol biosynthetic process
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0016310 phosphorylation
GO:0046488 phosphatidylinositol metabolic process
GO:0046854 phosphatidylinositol phosphorylation

Cellular Component:
GO:0001931 uropod
GO:0005829 cytosol
GO:0012505 endomembrane system
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK295587 - Homo sapiens cDNA FLJ54445 complete cds, highly similar to Phosphatidylinositol-4-phosphate 5-kinasetype-1 beta (EC 2.7.1.68).
AK292734 - Homo sapiens cDNA FLJ76965 complete cds, highly similar to Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type I, beta (PIP5K1B), transcript variant 2, mRNA.
X92493 - H.sapiens mRNA for STM-7 protein.
BC030587 - Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type I, beta, mRNA (cDNA clone MGC:26375 IMAGE:4823087), complete cds.
DQ894030 - Synthetic construct Homo sapiens clone IMAGE:100008490; FLH166690.01L; RZPDo839C0387D phosphatidylinositol-4-phosphate 5-kinase, type I, beta (PIP5K1B) gene, encodes complete protein.
DQ890874 - Synthetic construct clone IMAGE:100003504; FLH166694.01X; RZPDo839C0388D phosphatidylinositol-4-phosphate 5-kinase, type I, beta (PIP5K1B) gene, encodes complete protein.
KJ901875 - Synthetic construct Homo sapiens clone ccsbBroadEn_11269 PIP5K1B gene, encodes complete protein.
KJ905347 - Synthetic construct Homo sapiens clone ccsbBroadEn_14892 PIP5K1B gene, encodes complete protein.
U78581 - Human type I phosphatidylinositol-4-phosphate 5-kinase beta (STM7) mRNA, partial cds.
U78579 - Human type I phosphatidylinositol-4-phosphate 5-kinase beta (STM7) mRNA, partial cds.
U78580 - Human type I phosphatidylinositol-4-phosphate 5-kinase beta (STM7) mRNA, partial cds.
JD087556 - Sequence 68580 from Patent EP1572962.
JD361971 - Sequence 342995 from Patent EP1572962.
JD495648 - Sequence 476672 from Patent EP1572962.
JD535140 - Sequence 516164 from Patent EP1572962.
JD273430 - Sequence 254454 from Patent EP1572962.
JD042354 - Sequence 23378 from Patent EP1572962.
JD137603 - Sequence 118627 from Patent EP1572962.
JD504896 - Sequence 485920 from Patent EP1572962.
CU688922 - Synthetic construct Homo sapiens gateway clone IMAGE:100020346 5' read PIP5K1B mRNA.
JD357216 - Sequence 338240 from Patent EP1572962.
JD510263 - Sequence 491287 from Patent EP1572962.
JD133972 - Sequence 114996 from Patent EP1572962.
JD061448 - Sequence 42472 from Patent EP1572962.
JD245817 - Sequence 226841 from Patent EP1572962.
JD250679 - Sequence 231703 from Patent EP1572962.
JD565288 - Sequence 546312 from Patent EP1572962.
JD359658 - Sequence 340682 from Patent EP1572962.
JD550803 - Sequence 531827 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00562 - Inositol phosphate metabolism
hsa01100 - Metabolic pathways
hsa04070 - Phosphatidylinositol signaling system
hsa04144 - Endocytosis
hsa04666 - Fc gamma R-mediated phagocytosis
hsa04810 - Regulation of actin cytoskeleton

BioCyc Knowledge Library
PWY-6351 - D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY-6352 - 3-phosphoinositide biosynthesis
PWY-6371 - superpathway of inositol phosphate compounds

BioCarta from NCI Cancer Genome Anatomy Project
h_rhoPathway - Rho cell motility signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein O14986 (Reactome details) participates in the following event(s):

R-HSA-3772434 Phosphorylated DVL recruits PIP5K1B to the plasma membrane
R-HSA-3772436 DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2
R-HSA-1676082 PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
R-HSA-1675773 PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
R-HSA-1676145 PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
R-HSA-1676134 PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
R-HSA-1675810 PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
R-HSA-201688 WNT mediated activation of DVL
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-195721 Signaling by WNT
R-HSA-1483255 PI Metabolism
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-162582 Signal Transduction
R-HSA-1483257 Phospholipid metabolism
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-556833 Metabolism of lipids
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9L9, ENST00000265382.1, ENST00000265382.2, ENST00000265382.3, ENST00000265382.4, ENST00000265382.5, ENST00000265382.6, ENST00000265382.7, NM_003558, O14986, P78518, P78519, PI51B_HUMAN, Q5T5K6, Q5T5K8, Q5T5K9, Q5VZ00, Q7KYT5, Q8NHQ5, Q92749, STM7, uc004agu.1, uc004agu.2, uc004agu.3, uc004agu.4, uc004agu.5, uc004agu.6
UCSC ID: ENST00000265382.8
RefSeq Accession: NM_003558
Protein: O14986 (aka PI51B_HUMAN)
CCDS: CCDS6624.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.