Human Gene NANS (ENST00000210444.6) from GENCODE V44
Description: Homo sapiens N-acetylneuraminate synthase (NANS), mRNA. (from RefSeq NM_018946) RefSeq Summary (NM_018946): This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000210444.6 Gencode Gene: ENSG00000095380.11 Transcript (Including UTRs) Position: hg38 chr9:98,056,732-98,083,077 Size: 26,346 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr9:98,056,809-98,083,055 Size: 26,247 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NR45
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00520 - Amino sugar and nucleotide sugar metabolism hsa01100 - Metabolic pathways
BioCyc Knowledge Library PWY-6138 - CMP-N-acetylneuraminate biosynthesis I (eukaryotes)
Reactome (by CSHL, EBI, and GO)
Protein Q9NR45 (Reactome details) participates in the following event(s):
R-HSA-4084976 NANS converts ManNAc-6-P to Neu5Ac-9-P R-HSA-4085001 Sialic acid metabolism R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
