Human Gene CDC26 (ENST00000374206.4) from GENCODE V44
Description: Homo sapiens cell division cycle 26 (CDC26), mRNA. (from RefSeq NM_139286) RefSeq Summary (NM_139286): The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000374206.4 Gencode Gene: ENSG00000176386.9 Transcript (Including UTRs) Position: hg38 chr9:113,266,992-113,275,572 Size: 8,581 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr9:113,267,263-113,272,507 Size: 5,245 Coding Exon Count: 2
ID:CDC26_HUMAN DESCRIPTION: RecName: Full=Anaphase-promoting complex subunit CDC26; AltName: Full=Anaphase-promoting complex subunit 12; Short=APC12; AltName: Full=Cell division cycle protein 26 homolog; FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: The APC/C is composed of at least 12 subunits. INTERACTION: Q13042:CDC16; NbExp=3; IntAct=EBI-2555941, EBI-994830; SUBCELLULAR LOCATION: Nucleus (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the CDC26 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NHZ8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q8NHZ8 (Reactome details) participates in the following event(s):
R-HSA-141423 Binding of the MCC complex to the APC/C complex R-HSA-174070 Association of Cdh1 with the APC/C R-HSA-174224 Dissociation of Cdc20 from APC/C complex R-HSA-174119 Free APC/C phosphorylated by Plk1 R-HSA-174132 Free APC/C phosphorylated by Cyclin B:Cdc2 R-HSA-174139 Dissociation of phospho-Cdh1 from the APC/C complex R-HSA-174171 Association of Cyclin A with the APC/C R-HSA-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 R-HSA-179410 Association of Nek2A with MCC:APC/C R-HSA-174120 Association of Cyclin B:Cdc2 with Cdc20:APC/C complex R-HSA-174121 Association of Securin with Cdc20:APC/C complex R-HSA-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-174057 Multiubiquitination of APC/C-associated Cdh1 R-HSA-188371 Association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788708 CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788725 Cdh1:APC/C complex binds EHMT1:EHMT2 R-HSA-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex R-HSA-179417 Multiubiquitination of Nek2A R-HSA-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex R-HSA-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex R-HSA-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex R-HSA-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176412 Phosphorylation of the APC/C R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-2467813 Separation of Sister Chromatids R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-68882 Mitotic Anaphase R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-453276 Regulation of mitotic cell cycle R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-2559583 Cellular Senescence R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69620 Cell Cycle Checkpoints R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1280218 Adaptive Immune System R-HSA-2262752 Cellular responses to stress R-HSA-68886 M Phase R-HSA-69239 Synthesis of DNA R-HSA-1640170 Cell Cycle R-HSA-168256 Immune System R-HSA-8953897 Cellular responses to external stimuli R-HSA-69242 S Phase R-HSA-69306 DNA Replication
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