Human Gene SH3GLB2 (ENST00000372564.8) from GENCODE V44
Description: Homo sapiens SH3 domain containing GRB2 like, endophilin B2 (SH3GLB2), transcript variant 2, mRNA. (from RefSeq NM_020145)
Gencode Transcript: ENST00000372564.8
Gencode Gene: ENSG00000148341.18
Transcript (Including UTRs)
Position: hg38 chr9:129,007,036-129,028,331 Size: 21,296 Total Exon Count: 11 Strand: -
Coding Region
Position: hg38 chr9:129,008,684-129,028,154 Size: 19,471 Coding Exon Count: 11
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: SHLB2_HUMAN
DESCRIPTION: RecName: Full=Endophilin-B2; AltName: Full=SH3 domain-containing GRB2-like protein B2;
SUBUNIT: Homodimer, and heterodimer with SH3GLB1.INTERACTION: Q9Y371:SH3GLB1; NbExp=5; IntAct=EBI-749607, EBI-2623095;SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland.SIMILARITY: Belongs to the endophilin family.SIMILARITY: Contains 1 BAR domain.SIMILARITY: Contains 1 SH3 domain.SEQUENCE CAUTION: Sequence=AAG23792.1; Type=Frameshift; Positions=122, 128; Sequence=BAB47477.2; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR004148 - BAR_dom
IPR013606 - IRSp53/MIM_homology_IMD
IPR011511 - SH3_2
IPR001452 - SH3_domain
Pfam Domains: PF03114 - BAR domain
PF07653 - Variant SH3 domain
ModBase Predicted Comparative 3D Structure on Q9NR46
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC005843 - Homo sapiens SH3-domain GRB2-like endophilin B2, mRNA (cDNA clone IMAGE:2821405), partial cds.AF257319 - Homo sapiens SH3-containing protein SH3GLB2 mRNA, complete cds.BC014635 - Homo sapiens SH3-domain GRB2-like endophilin B2, mRNA (cDNA clone MGC:11029 IMAGE:3677306), complete cds.AF258589 - Homo sapiens PP578 mRNA, complete cds.BC008029 - Homo sapiens, clone IMAGE:3608989, mRNA.AF370433 - Homo sapiens PP9455 mRNA, complete cds.AF370426 - Homo sapiens PP6569 mRNA, complete cds.AB058751 - Homo sapiens KIAA1848 mRNA for KIAA1848 protein.JD299633 - Sequence 280657 from Patent EP1572962.JD114856 - Sequence 95880 from Patent EP1572962.JD128523 - Sequence 109547 from Patent EP1572962.JD106434 - Sequence 87458 from Patent EP1572962.JD054830 - Sequence 35854 from Patent EP1572962.AL832592 - Homo sapiens mRNA; cDNA DKFZp451L0716 (from clone DKFZp451L0716).JD396300 - Sequence 377324 from Patent EP1572962.JD466866 - Sequence 447890 from Patent EP1572962.JD084743 - Sequence 65767 from Patent EP1572962.JD171977 - Sequence 153001 from Patent EP1572962.JD530955 - Sequence 511979 from Patent EP1572962.JD222121 - Sequence 203145 from Patent EP1572962.JD281541 - Sequence 262565 from Patent EP1572962.JD559861 - Sequence 540885 from Patent EP1572962.KJ894359 - Synthetic construct Homo sapiens clone ccsbBroadEn_03753 SH3GLB2 gene, encodes complete protein.AB384306 - Synthetic construct DNA, clone: pF1KSDA1848, Homo sapiens SH3GLB2 gene for SH3 domain GRB2-like protein B2, complete cds, without stop codon, in Flexi system.EU832345 - Synthetic construct Homo sapiens clone HAIB:100067374; DKFZo008G1127 SH3-domain GRB2-like endophilin B2 protein (SH3GLB2) gene, encodes complete protein.EU832430 - Synthetic construct Homo sapiens clone HAIB:100067459; DKFZo004G1128 SH3-domain GRB2-like endophilin B2 protein (SH3GLB2) gene, encodes complete protein.JD024326 - Sequence 5350 from Patent EP1572962.JD422443 - Sequence 403467 from Patent EP1572962.JD075902 - Sequence 56926 from Patent EP1572962.JD453117 - Sequence 434141 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04144 - Endocytosis
BioCarta from NCI Cancer Genome Anatomy Project h_cblPathway - CBL mediated ligand-induced downregulation of EGF receptors
Other Names for This Gene
Alternate Gene Symbols: A6NC47, A8MPS4, ENST00000372564.1, ENST00000372564.2, ENST00000372564.3, ENST00000372564.4, ENST00000372564.5, ENST00000372564.6, ENST00000372564.7, KIAA1848, NM_020145, PP578, Q8WY61, Q96JH9, Q9NR46, SHLB2_HUMAN, uc004bwv.1, uc004bwv.2, uc004bwv.3, uc004bwv.4, uc004bwv.5, uc004bwv.6UCSC ID: ENST00000372564.8RefSeq Accession: NM_020145
Protein: Q9NR46
(aka SHLB2_HUMAN or SHB2_HUMAN)
CCDS: CCDS6916.1 , CCDS69680.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.