Human Gene SH3GLB2 (ENST00000372564.8) from GENCODE V44
  Description: Homo sapiens SH3 domain containing GRB2 like, endophilin B2 (SH3GLB2), transcript variant 2, mRNA. (from RefSeq NM_020145)
Gencode Transcript: ENST00000372564.8
Gencode Gene: ENSG00000148341.18
Transcript (Including UTRs)
   Position: hg38 chr9:129,007,036-129,028,331 Size: 21,296 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr9:129,008,684-129,028,154 Size: 19,471 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:129,007,036-129,028,331)mRNA (may differ from genome)Protein (395 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SHLB2_HUMAN
DESCRIPTION: RecName: Full=Endophilin-B2; AltName: Full=SH3 domain-containing GRB2-like protein B2;
SUBUNIT: Homodimer, and heterodimer with SH3GLB1.
INTERACTION: Q9Y371:SH3GLB1; NbExp=5; IntAct=EBI-749607, EBI-2623095;
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland.
SIMILARITY: Belongs to the endophilin family.
SIMILARITY: Contains 1 BAR domain.
SIMILARITY: Contains 1 SH3 domain.
SEQUENCE CAUTION: Sequence=AAG23792.1; Type=Frameshift; Positions=122, 128; Sequence=BAB47477.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 112.77 RPKM in Pituitary
Total median expression: 2618.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -115.90177-0.655 Picture PostScript Text
3' UTR -681.901648-0.414 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004148 - BAR_dom
IPR013606 - IRSp53/MIM_homology_IMD
IPR011511 - SH3_2
IPR001452 - SH3_domain

Pfam Domains:
PF03114 - BAR domain
PF07653 - Variant SH3 domain

ModBase Predicted Comparative 3D Structure on Q9NR46
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0045296 cadherin binding

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC005843 - Homo sapiens SH3-domain GRB2-like endophilin B2, mRNA (cDNA clone IMAGE:2821405), partial cds.
AF257319 - Homo sapiens SH3-containing protein SH3GLB2 mRNA, complete cds.
BC014635 - Homo sapiens SH3-domain GRB2-like endophilin B2, mRNA (cDNA clone MGC:11029 IMAGE:3677306), complete cds.
AF258589 - Homo sapiens PP578 mRNA, complete cds.
BC008029 - Homo sapiens, clone IMAGE:3608989, mRNA.
AF370433 - Homo sapiens PP9455 mRNA, complete cds.
AF370426 - Homo sapiens PP6569 mRNA, complete cds.
AB058751 - Homo sapiens KIAA1848 mRNA for KIAA1848 protein.
JD299633 - Sequence 280657 from Patent EP1572962.
JD114856 - Sequence 95880 from Patent EP1572962.
JD128523 - Sequence 109547 from Patent EP1572962.
JD106434 - Sequence 87458 from Patent EP1572962.
JD054830 - Sequence 35854 from Patent EP1572962.
AL832592 - Homo sapiens mRNA; cDNA DKFZp451L0716 (from clone DKFZp451L0716).
JD396300 - Sequence 377324 from Patent EP1572962.
JD466866 - Sequence 447890 from Patent EP1572962.
JD084743 - Sequence 65767 from Patent EP1572962.
JD171977 - Sequence 153001 from Patent EP1572962.
JD530955 - Sequence 511979 from Patent EP1572962.
JD222121 - Sequence 203145 from Patent EP1572962.
JD281541 - Sequence 262565 from Patent EP1572962.
JD559861 - Sequence 540885 from Patent EP1572962.
KJ894359 - Synthetic construct Homo sapiens clone ccsbBroadEn_03753 SH3GLB2 gene, encodes complete protein.
AB384306 - Synthetic construct DNA, clone: pF1KSDA1848, Homo sapiens SH3GLB2 gene for SH3 domain GRB2-like protein B2, complete cds, without stop codon, in Flexi system.
EU832345 - Synthetic construct Homo sapiens clone HAIB:100067374; DKFZo008G1127 SH3-domain GRB2-like endophilin B2 protein (SH3GLB2) gene, encodes complete protein.
EU832430 - Synthetic construct Homo sapiens clone HAIB:100067459; DKFZo004G1128 SH3-domain GRB2-like endophilin B2 protein (SH3GLB2) gene, encodes complete protein.
JD024326 - Sequence 5350 from Patent EP1572962.
JD422443 - Sequence 403467 from Patent EP1572962.
JD075902 - Sequence 56926 from Patent EP1572962.
JD453117 - Sequence 434141 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04144 - Endocytosis

BioCarta from NCI Cancer Genome Anatomy Project
h_cblPathway - CBL mediated ligand-induced downregulation of EGF receptors

-  Other Names for This Gene
  Alternate Gene Symbols: A6NC47, A8MPS4, ENST00000372564.1, ENST00000372564.2, ENST00000372564.3, ENST00000372564.4, ENST00000372564.5, ENST00000372564.6, ENST00000372564.7, KIAA1848, NM_020145, PP578, Q8WY61, Q96JH9, Q9NR46, SHLB2_HUMAN, uc004bwv.1, uc004bwv.2, uc004bwv.3, uc004bwv.4, uc004bwv.5, uc004bwv.6
UCSC ID: ENST00000372564.8
RefSeq Accession: NM_020145
Protein: Q9NR46 (aka SHLB2_HUMAN or SHB2_HUMAN)
CCDS: CCDS6916.1, CCDS69680.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.