Human Gene NTNG2 (ENST00000393229.4) from GENCODE V44
  Description: Homo sapiens netrin G2 (NTNG2), mRNA. (from RefSeq NM_032536)
Gencode Transcript: ENST00000393229.4
Gencode Gene: ENSG00000196358.12
Transcript (Including UTRs)
   Position: hg38 chr9:132,162,058-132,244,526 Size: 82,469 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr9:132,166,832-132,242,111 Size: 75,280 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:132,162,058-132,244,526)mRNA (may differ from genome)Protein (530 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NTNG2_HUMAN
DESCRIPTION: RecName: Full=Netrin-G2; AltName: Full=Laminet-2; Flags: Precursor;
FUNCTION: Promotes neurite outgrowth of both axons and dendrites (By similarity).
SUBUNIT: Interacts with LRRC4 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity).
PTM: N-glycosylated (By similarity).
SIMILARITY: Contains 3 laminin EGF-like domains.
SIMILARITY: Contains 1 laminin N-terminal domain.
SEQUENCE CAUTION: Sequence=BAB47486.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NTNG2
Diseases sorted by gene-association score: rett syndrome (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.29 RPKM in Brain - Hippocampus
Total median expression: 97.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -277.50665-0.417 Picture PostScript Text
3' UTR -1009.502415-0.418 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS
IPR013111 - EGF_extracell
IPR002049 - EGF_laminin
IPR008211 - Laminin_N

Pfam Domains:
PF07974 - EGF-like domain
PF00053 - Laminin EGF domain
PF00055 - Laminin N-terminal (Domain VI)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3TBD - X-ray MuPIT 3ZYG - X-ray MuPIT 3ZYI - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q96CW9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0030154 cell differentiation

Cellular Component:
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0031225 anchored component of membrane
GO:0045171 intercellular bridge
GO:0046658 anchored component of plasma membrane
GO:0090543 Flemming body


-  Descriptions from all associated GenBank mRNAs
  AY358165 - Homo sapiens clone DNA212353 LHLL9381 (UNQ9381) mRNA, complete cds.
AB058760 - Homo sapiens KIAA1857 mRNA for KIAA1857 protein.
BC013770 - Homo sapiens netrin G2, mRNA (cDNA clone MGC:21884 IMAGE:4344617), complete cds.
AB384308 - Synthetic construct DNA, clone: pF1KSDA1857, Homo sapiens NTNG2 gene for netrin-G2 precursor, complete cds, without stop codon, in Flexi system.
AF131842 - Homo sapiens clone 25187 and 25188 mRNA sequences, partial cds.
JD480127 - Sequence 461151 from Patent EP1572962.
JD191837 - Sequence 172861 from Patent EP1572962.
JD405645 - Sequence 386669 from Patent EP1572962.
JD446111 - Sequence 427135 from Patent EP1572962.
JD390186 - Sequence 371210 from Patent EP1572962.
JD462220 - Sequence 443244 from Patent EP1572962.
JD566629 - Sequence 547653 from Patent EP1572962.
JD494125 - Sequence 475149 from Patent EP1572962.
JD426305 - Sequence 407329 from Patent EP1572962.
JD492146 - Sequence 473170 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96CW9 (Reactome details) participates in the following event(s):

R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000393229.1, ENST00000393229.2, ENST00000393229.3, KIAA1857, LMNT2, NM_032536, NTNG2_HUMAN, Q5JUJ2, Q6UXY0, Q96CW9, Q96JH0, uc004cbh.1, uc004cbh.2, uc004cbh.3, uc004cbh.4, UNQ9381/PRO34206
UCSC ID: ENST00000393229.4
RefSeq Accession: NM_032536
Protein: Q96CW9 (aka NTNG2_HUMAN or NTG2_HUMAN)
CCDS: CCDS6946.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.