Human Gene NTNG2 (ENST00000393229.4) from GENCODE V44
Description: Homo sapiens netrin G2 (NTNG2), mRNA. (from RefSeq NM_032536)
Gencode Transcript: ENST00000393229.4
Gencode Gene: ENSG00000196358.12
Transcript (Including UTRs)
Position: hg38 chr9:132,162,058-132,244,526 Size: 82,469 Total Exon Count: 8 Strand: +
Coding Region
Position: hg38 chr9:132,166,832-132,242,111 Size: 75,280 Coding Exon Count: 7
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: NTNG2_HUMAN
DESCRIPTION: RecName: Full=Netrin-G2; AltName: Full=Laminet-2; Flags: Precursor;
FUNCTION: Promotes neurite outgrowth of both axons and dendrites (By similarity).SUBUNIT: Interacts with LRRC4 (By similarity).SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity).PTM: N-glycosylated (By similarity).SIMILARITY: Contains 3 laminin EGF-like domains.SIMILARITY: Contains 1 laminin N-terminal domain.SEQUENCE CAUTION: Sequence=BAB47486.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS
IPR013111 - EGF_extracell
IPR002049 - EGF_laminin
IPR008211 - Laminin_N
Pfam Domains: PF07974 - EGF-like domain
PF00053 - Laminin EGF domain
PF00055 - Laminin N-terminal (Domain VI)
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q96CW9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AY358165 - Homo sapiens clone DNA212353 LHLL9381 (UNQ9381) mRNA, complete cds.AB058760 - Homo sapiens KIAA1857 mRNA for KIAA1857 protein.BC013770 - Homo sapiens netrin G2, mRNA (cDNA clone MGC:21884 IMAGE:4344617), complete cds.AB384308 - Synthetic construct DNA, clone: pF1KSDA1857, Homo sapiens NTNG2 gene for netrin-G2 precursor, complete cds, without stop codon, in Flexi system.AF131842 - Homo sapiens clone 25187 and 25188 mRNA sequences, partial cds.JD480127 - Sequence 461151 from Patent EP1572962.JD191837 - Sequence 172861 from Patent EP1572962.JD405645 - Sequence 386669 from Patent EP1572962.JD446111 - Sequence 427135 from Patent EP1572962.JD390186 - Sequence 371210 from Patent EP1572962.JD462220 - Sequence 443244 from Patent EP1572962.JD566629 - Sequence 547653 from Patent EP1572962.JD494125 - Sequence 475149 from Patent EP1572962.JD426305 - Sequence 407329 from Patent EP1572962.JD492146 - Sequence 473170 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Protein Q96CW9 (Reactome details) participates in the following event(s):R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins
Other Names for This Gene
Alternate Gene Symbols: ENST00000393229.1, ENST00000393229.2, ENST00000393229.3, KIAA1857, LMNT2, NM_032536, NTNG2_HUMAN, Q5JUJ2, Q6UXY0, Q96CW9, Q96JH0, uc004cbh.1, uc004cbh.2, uc004cbh.3, uc004cbh.4, UNQ9381/PRO34206UCSC ID: ENST00000393229.4RefSeq Accession: NM_032536
Protein: Q96CW9
(aka NTNG2_HUMAN or NTG2_HUMAN)
CCDS: CCDS6946.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.