Human Gene ASB9 (ENST00000380485.7) from GENCODE V44
Description: Homo sapiens ankyrin repeat and SOCS box containing 9 (ASB9), transcript variant 2, mRNA. (from RefSeq NM_024087) RefSeq Summary (NM_024087): This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]. Gencode Transcript: ENST00000380485.7 Gencode Gene: ENSG00000102048.16 Transcript (Including UTRs) Position: hg38 chrX:15,243,987-15,270,061 Size: 26,075 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chrX:15,248,715-15,269,874 Size: 21,160 Coding Exon Count: 6
ID:ASB9_HUMAN DESCRIPTION: RecName: Full=Ankyrin repeat and SOCS box protein 9; Short=ASB-9; FUNCTION: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. PATHWAY: Protein modification; protein ubiquitination. INTERACTION: P12277:CKB; NbExp=3; IntAct=EBI-745641, EBI-357706; Q9NWT6:HIF1AN; NbExp=3; IntAct=EBI-745641, EBI-745632; SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Predominantly expressed in testis, kidney, and liver. DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin- protein ligase complexes (By similarity). SIMILARITY: Contains 6 ANK repeats. SIMILARITY: Contains 1 SOCS box domain. SEQUENCE CAUTION: Sequence=CAB45706.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96DX5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0016567 protein ubiquitination GO:0035556 intracellular signal transduction GO:0043687 post-translational protein modification GO:0045732 positive regulation of protein catabolic process
US Server
