Human Gene ADGRG2 (ENST00000360279.8) from GENCODE V44
  Description: Homo sapiens adhesion G protein-coupled receptor G2 (ADGRG2), transcript variant 7, mRNA. (from RefSeq NM_001184835)
RefSeq Summary (NM_001184836): This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000360279.8
Gencode Gene: ENSG00000173698.18
Transcript (Including UTRs)
   Position: hg38 chrX:18,989,314-19,122,559 Size: 133,246 Total Exon Count: 27 Strand: -
Coding Region
   Position: hg38 chrX:18,990,864-19,068,834 Size: 77,971 Coding Exon Count: 25 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:18,989,314-19,122,559)mRNA (may differ from genome)Protein (995 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsLynx
MalacardsMGIneXtProtOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR64_HUMAN
DESCRIPTION: RecName: Full=G-protein coupled receptor 64; AltName: Full=Human epididymis-specific protein 6; Short=He6; Flags: Precursor;
FUNCTION: Could be involved in a signal transduction pathway controlling epididymal function and male fertility.
SUBUNIT: Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety (Probable).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia.
PTM: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (Potential).
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADGRG2
Diseases sorted by gene-association score: vas deferens, congenital bilateral aplasia of, x-linked* (900), congenital bilateral absence of vas deferens* (543)
* = Manually curated disease association

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.34 RPKM in Adipose - Visceral (Omentum)
Total median expression: 29.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.00164-0.457 Picture PostScript Text
3' UTR -368.801550-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017981 - GPCR_2-like
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS
IPR000203 - GPS_dom

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif

ModBase Predicted Comparative 3D Structure on Q8IZP9
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007283 spermatogenesis

Cellular Component:
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC063315 - Homo sapiens cDNA clone IMAGE:30340382, containing frame-shift errors.
X81892 - H.sapiens mRNA for HE6 Tm7 receptor.
AF538954 - Homo sapiens HE6 receptor long splice variant mRNA, complete cds; alternatively spliced.
AF539455 - Homo sapiens HE6 receptor splice variant d2 (GPR64) mRNA, complete cds; alternatively spliced.
AF539456 - Homo sapiens HE6 receptor splice variant d3 (GPR64) mRNA, complete cds; alternatively spliced.
AY143364 - Homo sapiens HE6 heptahelical receptor splice variant 21 mRNA, complete cds.
AY143365 - Homo sapiens HE6 heptahelical receptor splice variant 24 mRNA, complete cds.
AY143366 - Homo sapiens HE6 heptahelical receptor splice variant d1 mRNA, complete cds.
AY143367 - Homo sapiens HE6 heptahelical receptor splice variant 23 mRNA, complete cds.
AY148343 - Homo sapiens HE6 heptahelical receptor splice variant delta exon 28 mRNA, complete cds; alternatively spliced.
BC099901 - Homo sapiens G protein-coupled receptor 64, mRNA (cDNA clone MGC:104454 IMAGE:30349668), complete cds.
BC113978 - Homo sapiens G protein-coupled receptor 64, mRNA (cDNA clone MGC:138739 IMAGE:40081713), complete cds.
BC113979 - Homo sapiens G protein-coupled receptor 64, mRNA (cDNA clone MGC:138738 IMAGE:40081711), complete cds.
AK291012 - Homo sapiens cDNA FLJ77493 complete cds, highly similar to Homo sapiens G protein-coupled receptor 64 (GPR64), mRNA.
KJ902066 - Synthetic construct Homo sapiens clone ccsbBroadEn_11460 GPR64 gene, encodes complete protein.
JD439324 - Sequence 420348 from Patent EP1572962.
JD392358 - Sequence 373382 from Patent EP1572962.
JD474270 - Sequence 455294 from Patent EP1572962.
AK309439 - Homo sapiens cDNA, FLJ99480.
JD567015 - Sequence 548039 from Patent EP1572962.
JD514367 - Sequence 495391 from Patent EP1572962.
JD113063 - Sequence 94087 from Patent EP1572962.
JD553564 - Sequence 534588 from Patent EP1572962.
AK090402 - Homo sapiens mRNA for FLJ00282 protein.
MP014985 - Sequence 188 from Patent WO2019016252.

-  Other Names for This Gene
  Alternate Gene Symbols: B1AWB3, B1AWB4, B1AWB6, B1AWB7, ENST00000360279.1, ENST00000360279.2, ENST00000360279.3, ENST00000360279.4, ENST00000360279.5, ENST00000360279.6, ENST00000360279.7, GPR64, GPR64_HUMAN, HE6, NM_001184835, O00406, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4, Q8IZP9, TM7LN2, uc004cza.1, uc004cza.2, uc004cza.3, uc004cza.4
UCSC ID: ENST00000360279.8
RefSeq Accession: NM_001184836
Protein: Q8IZP9 (aka GPR64_HUMAN or GP64_HUMAN)
CCDS: CCDS14191.1, CCDS43921.1, CCDS43922.1, CCDS43923.1, CCDS55376.1, CCDS55377.1, CCDS55378.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.