Human Gene ADGRG2 (ENST00000379876.5) from GENCODE V44
Description: Homo sapiens adhesion G protein-coupled receptor G2 (ADGRG2), transcript variant 8, mRNA. (from RefSeq NM_001184836) RefSeq Summary (NM_001184836): This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000379876.5 Gencode Gene: ENSG00000173698.18 Transcript (Including UTRs) Position: hg38 chrX:18,989,309-19,122,637 Size: 133,329 Total Exon Count: 27 Strand: - Coding Region Position: hg38 chrX:18,990,864-19,068,834 Size: 77,971 Coding Exon Count: 25
ID:GPR64_HUMAN DESCRIPTION: RecName: Full=G-protein coupled receptor 64; AltName: Full=Human epididymis-specific protein 6; Short=He6; Flags: Precursor; FUNCTION: Could be involved in a signal transduction pathway controlling epididymal function and male fertility. SUBUNIT: Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety (Probable). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. PTM: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (Potential). SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. SIMILARITY: Contains 1 GPS domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IZP9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.