Human Gene CHST7 (ENST00000276055.4) from GENCODE V44
Description: Homo sapiens carbohydrate sulfotransferase 7 (CHST7), mRNA. (from RefSeq NM_019886) RefSeq Summary (NM_019886): This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]. Gencode Transcript: ENST00000276055.4 Gencode Gene: ENSG00000147119.4 Transcript (Including UTRs) Position: hg38 chrX:46,573,765-46,598,496 Size: 24,732 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chrX:46,573,932-46,575,392 Size: 1,461 Coding Exon Count: 1
ID:CHST7_HUMAN DESCRIPTION: RecName: Full=Carbohydrate sulfotransferase 7; EC=2.8.2.-; EC=2.8.2.17; AltName: Full=Chondroitin 6-sulfotransferase 2; Short=C6ST-2; AltName: Full=Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; Short=GST-5; AltName: Full=N-acetylglucosamine 6-O-sulfotransferase 4; Short=GlcNAc6ST-4; Short=Gn6st-4; FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). TISSUE SPECIFICITY: Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin. SIMILARITY: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NS84
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0005976 polysaccharide metabolic process GO:0006044 N-acetylglucosamine metabolic process GO:0006790 sulfur compound metabolic process GO:0030206 chondroitin sulfate biosynthetic process
US Server
