Human Gene PFKFB1 (ENST00000375006.8) from GENCODE V44
Description: Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1), transcript variant 4, non-coding RNA. (from RefSeq NR_073450) RefSeq Summary (NM_002625): This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]. Gencode Transcript: ENST00000375006.8 Gencode Gene: ENSG00000158571.11 Transcript (Including UTRs) Position: hg38 chrX:54,932,961-54,994,188 Size: 61,228 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chrX:54,933,403-54,994,007 Size: 60,605 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16118
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P16118 (Reactome details) participates in the following event(s):
R-HSA-163773 Phosphorylation of PF2K-Pase by PKA catalytic subunit R-HSA-163750 Dephosphorylation of phosphoPFKFB1 by PP2A complex R-HSA-70262 Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate R-HSA-71802 D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP R-HSA-70171 Glycolysis R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors R-HSA-70326 Glucose metabolism R-HSA-163685 Energy Metabolism R-HSA-71387 Metabolism of carbohydrates R-HSA-1430728 Metabolism
US Server
