Human Gene GDPD2 (ENST00000374382.4) from GENCODE V44
Description: Homo sapiens glycerophosphodiester phosphodiesterase domain containing 2 (GDPD2), transcript variant 2, mRNA. (from RefSeq NM_017711) RefSeq Summary (NM_017711): This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. This protein may have a role in osteoblast differentiation and growth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. Gencode Transcript: ENST00000374382.4 Gencode Gene: ENSG00000130055.14 Transcript (Including UTRs) Position: hg38 chrX:70,423,314-70,433,381 Size: 10,068 Total Exon Count: 16 Strand: + Coding Region Position: hg38 chrX:70,424,985-70,433,086 Size: 8,102 Coding Exon Count: 15
ID:GDPD2_HUMAN DESCRIPTION: RecName: Full=Glycerophosphoinositol inositolphosphodiesterase GDPD2; EC=3.1.4.43; AltName: Full=Glycerophosphodiester phosphodiesterase 3; AltName: Full=Glycerophosphodiester phosphodiesterase domain-containing protein 2; AltName: Full=Osteoblast differentiation promoting factor; FUNCTION: Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4- phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity). CATALYTIC ACTIVITY: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = glycerol + 1D-myo-inositol 1-phosphate. COFACTOR: Calcium. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with the actin cytoskeleton (By similarity). SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase family. SIMILARITY: Contains 1 GDPD domain. CAUTION: The catalytic domain of GDPD2 is oriented extracellularly; Glycerophosphoinositol is hydrolyzed in the medium of cells overexpressing Gdpd2, whereas intracellular levels of glycerophosphoinositol is not affected. SEQUENCE CAUTION: Sequence=BAA91014.1; Type=Frameshift; Positions=397;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03009 - Glycerophosphoryl diester phosphodiesterase family
ModBase Predicted Comparative 3D Structure on Q9HCC8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
