Human Gene TAF9B (ENST00000341864.6) from GENCODE V44
Description: Homo sapiens TATA-box binding protein associated factor 9b (TAF9B), mRNA. (from RefSeq NM_015975) RefSeq Summary (NM_015975): Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000341864.6 Gencode Gene: ENSG00000187325.5 Transcript (Including UTRs) Position: hg38 chrX:78,129,748-78,139,650 Size: 9,903 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chrX:78,131,610-78,139,611 Size: 8,002 Coding Exon Count: 7
ID:TAF9B_HUMAN DESCRIPTION: RecName: Full=Transcription initiation factor TFIID subunit 9B; AltName: Full=Neuronal cell death-related protein 7; Short=DN-7; AltName: Full=Transcription initiation factor TFIID subunit 9-like; AltName: Full=Transcription-associated factor TAFII31L; FUNCTION: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. SUBUNIT: Binds TAF5 and TAF6. Component of TFIID and the TATA- binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription. SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the TAF9 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HBM6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0036459 thiol-dependent ubiquitinyl hydrolase activity GO:0044212 transcription regulatory region DNA binding GO:0046982 protein heterodimerization activity GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly GO:0004402 histone acetyltransferase activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006352 DNA-templated transcription, initiation GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0016579 protein deubiquitination GO:0030307 positive regulation of cell growth GO:0043066 negative regulation of apoptotic process GO:0043966 histone H3 acetylation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050821 protein stabilization GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:1901796 regulation of signal transduction by p53 class mediator GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BC071649 - Homo sapiens TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa, mRNA (cDNA clone MGC:87820 IMAGE:5246715), complete cds. BC009566 - Homo sapiens TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa, mRNA (cDNA clone MGC:12251 IMAGE:3996687), complete cds. JD287375 - Sequence 268399 from Patent EP1572962. JD323375 - Sequence 304399 from Patent EP1572962. JD337969 - Sequence 318993 from Patent EP1572962. JD344590 - Sequence 325614 from Patent EP1572962. JD172115 - Sequence 153139 from Patent EP1572962. BC146952 - Homo sapiens TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa, mRNA (cDNA clone MGC:182055 IMAGE:9056880), complete cds. BC146960 - Homo sapiens TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa, mRNA (cDNA clone MGC:182063 IMAGE:9056888), complete cds. JD328585 - Sequence 309609 from Patent EP1572962. JD440723 - Sequence 421747 from Patent EP1572962. JD503835 - Sequence 484859 from Patent EP1572962. BC010350 - Homo sapiens TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa, mRNA (cDNA clone MGC:13324 IMAGE:4276335), complete cds. JD331978 - Sequence 313002 from Patent EP1572962. JD551307 - Sequence 532331 from Patent EP1572962. JD124095 - Sequence 105119 from Patent EP1572962. AF220509 - Homo sapiens transcription associated factor TAFII31L mRNA, complete cds. AF077053 - Homo sapiens neuronal cell death-related protein mRNA, complete cds. JD239361 - Sequence 220385 from Patent EP1572962. JD069014 - Sequence 50038 from Patent EP1572962. JD289535 - Sequence 270559 from Patent EP1572962. JD291347 - Sequence 272371 from Patent EP1572962. JD551383 - Sequence 532407 from Patent EP1572962. JD346102 - Sequence 327126 from Patent EP1572962. AK312579 - Homo sapiens cDNA, FLJ92954, highly similar to Homo sapiens TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa (TAF9L), mRNA. DQ891928 - Synthetic construct clone IMAGE:100004558; FLH181504.01X; RZPDo839E02136D TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa (TAF9B) gene, encodes complete protein. KJ898934 - Synthetic construct Homo sapiens clone ccsbBroadEn_08328 TAF9B gene, encodes complete protein. DQ895115 - Synthetic construct Homo sapiens clone IMAGE:100009575; FLH181500.01L; RZPDo839E02135D TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa (TAF9B) gene, encodes complete protein. AB529179 - Synthetic construct DNA, clone: pF1KB7526, Homo sapiens TAF9B gene for TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03022 - Basal transcription factors
Reactome (by CSHL, EBI, and GO)
Protein Q9HBM6 (Reactome details) participates in the following event(s):
R-HSA-109636 Recognition and Binding of Core Promoter Elements by TFIID R-HSA-73946 Abortive initiation R-HSA-75856 Abortive Initiation Before Second Transition R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript R-HSA-167474 Abortive HIV-1 Initiation Before Second Transition R-HSA-167477 Abortive HIV-1 initiation after formation of the first phosphodiester bond R-HSA-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP R-HSA-75861 NTP Binds Active Site of RNA Polymerase II R-HSA-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released R-HSA-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex R-HSA-75862 Fall Back to Closed Pre-initiation Complex R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition R-HSA-167134 Newly formed phosphodiester bond stabilized and PPi released R-HSA-167130 Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP R-HSA-167118 NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex R-HSA-167484 Fall Back to Closed Pre-initiation Complex R-HSA-167097 HIV Promoter Opening: First Transition R-HSA-6805399 TAF1 phosphorylates TP53 R-HSA-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex R-HSA-5690080 USP3,SAGA deubiquitinate Histone H2A,H2B R-HSA-75095 Binding of TFIIE to the growing preinitiation complex R-HSA-109639 Formation of the closed pre-initiation complex R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167161 HIV Transcription Initiation R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-167172 Transcription of the HIV genome R-HSA-73857 RNA Polymerase II Transcription R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-74160 Gene expression (Transcription) R-HSA-5633007 Regulation of TP53 Activity R-HSA-5689880 Ub-specific processing proteases R-HSA-162587 HIV Life Cycle R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-5688426 Deubiquitination R-HSA-162906 HIV Infection R-HSA-212436 Generic Transcription Pathway R-HSA-597592 Post-translational protein modification R-HSA-5663205 Infectious disease R-HSA-392499 Metabolism of proteins R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
