Human Gene APOOL (ENST00000373173.7) from GENCODE V44
  Description: Homo sapiens apolipoprotein O like (APOOL), mRNA. (from RefSeq NM_198450)
RefSeq Summary (NM_198450): This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000373173.7
Gencode Gene: ENSG00000155008.16
Transcript (Including UTRs)
   Position: hg38 chrX:85,003,877-85,093,315 Size: 89,439 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chrX:85,003,913-85,087,678 Size: 83,766 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:85,003,877-85,093,315)mRNA (may differ from genome)Protein (268 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: APOOL_HUMAN
DESCRIPTION: RecName: Full=Apolipoprotein O-like; AltName: Full=Protein FAM121A; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the apolipoprotein O family.
SEQUENCE CAUTION: Sequence=CAI42458.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.82 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 82.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.0036-0.278 Picture PostScript Text
3' UTR -1661.355637-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019166 - Apolipoprotein_O

Pfam Domains:
PF09769 - Apolipoprotein O

ModBase Predicted Comparative 3D Structure on Q6UXV4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0002576 platelet degranulation
GO:0042407 cristae formation

Cellular Component:
GO:0005576 extracellular region
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031093 platelet alpha granule lumen
GO:0061617 MICOS complex


-  Descriptions from all associated GenBank mRNAs
  AK130506 - Homo sapiens cDNA FLJ26996 fis, clone SLV04609.
BC107095 - Homo sapiens cDNA clone IMAGE:40015612.
BC107096 - Homo sapiens apolipoprotein O-like, mRNA (cDNA clone MGC:129748 IMAGE:40015614), complete cds.
AY358193 - Homo sapiens clone DNA143521 AAIR8193 (UNQ8193) mRNA, complete cds.
CR749250 - Homo sapiens mRNA; cDNA DKFZp779P1227 (from clone DKFZp779P1227).
KJ895532 - Synthetic construct Homo sapiens clone ccsbBroadEn_04926 APOOL gene, encodes complete protein.
JD353762 - Sequence 334786 from Patent EP1572962.
JD411132 - Sequence 392156 from Patent EP1572962.
JD486431 - Sequence 467455 from Patent EP1572962.
AK096909 - Homo sapiens cDNA FLJ39590 fis, clone SKNMC1000079.
JD185858 - Sequence 166882 from Patent EP1572962.
JD101911 - Sequence 82935 from Patent EP1572962.
JD381246 - Sequence 362270 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6UXV4 (Reactome details) participates in the following event(s):

R-HSA-481007 Exocytosis of platelet alpha granule contents
R-HSA-8949613 Cristae formation
R-HSA-114608 Platelet degranulation
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: APOOL_HUMAN, CXorf33, ENST00000373173.1, ENST00000373173.2, ENST00000373173.3, ENST00000373173.4, ENST00000373173.5, ENST00000373173.6, FAM121A, NM_198450, Q3KNU7, Q5H9D1, Q6UXV4, uc004eem.1, uc004eem.2, uc004eem.3, uc004eem.4, uc004eem.5, UNQ8193/PRO23204
UCSC ID: ENST00000373173.7
RefSeq Accession: NM_198450
Protein: Q6UXV4 (aka APOOL_HUMAN)
CCDS: CCDS48138.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.