Human Gene PCDH11X (ENST00000406881.3) from GENCODE V44
Description: Homo sapiens protocadherin 11 X-linked (PCDH11X), transcript variant e, mRNA. (from RefSeq NM_001168360) RefSeq Summary (NM_001168360): This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. Gencode Transcript: ENST00000406881.3 Gencode Gene: ENSG00000102290.23 Transcript (Including UTRs) Position: hg38 chrX:91,835,505-92,619,076 Size: 783,572 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chrX:91,835,505-92,618,940 Size: 783,436 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZA7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
