Human Gene H2BW1 (ENST00000217926.7) from GENCODE V44
Description: Homo sapiens H2B.W histone 1 (H2BW1), mRNA. (from RefSeq NM_001002916) RefSeq Summary (NM_001002916): Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Oct 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000217926.7 Gencode Gene: ENSG00000123569.10 Transcript (Including UTRs) Position: hg38 chrX:104,011,147-104,013,708 Size: 2,562 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chrX:104,012,712-104,013,576 Size: 865 Coding Exon Count: 2
ID:H2BWT_HUMAN DESCRIPTION: RecName: Full=Histone H2B type W-T; AltName: Full=H2B histone family member W testis-specific; FUNCTION: Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. SUBCELLULAR LOCATION: Nucleus membrane. Chromosome. TISSUE SPECIFICITY: Testis-specific. Present in sperm cells (at protein level). MISCELLANEOUS: In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is the target of monoubiquitination. MISCELLANEOUS: Ortholog in primates, but not in rodents. SIMILARITY: Belongs to the histone H2B family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z2G1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0046982 protein heterodimerization activity
US Server
Sequence and Links to Tools and Databases 
