Human Gene RBM41 (ENST00000372487.5) from GENCODE V44
  Description: May bind RNA (Potential). (from UniProt Q96IZ5)
Gencode Transcript: ENST00000372487.5
Gencode Gene: ENSG00000089682.17
Transcript (Including UTRs)
   Position: hg38 chrX:107,064,420-107,118,800 Size: 54,381 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chrX:107,065,754-107,118,773 Size: 53,020 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:107,064,420-107,118,800)mRNA (may differ from genome)Protein (405 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: RBM41_HUMAN
DESCRIPTION: RecName: Full=RNA-binding protein 41; AltName: Full=RNA-binding motif protein 41;
FUNCTION: May bind RNA (Potential).
SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.08 RPKM in Testis
Total median expression: 77.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.1027-0.152 Picture PostScript Text
3' UTR -250.801334-0.188 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2CPX - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q96IZ5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030626 U12 snRNA binding
GO:0097157 pre-mRNA intronic binding

Biological Process:
GO:0000398 mRNA splicing, via spliceosome
GO:0032502 developmental process

Cellular Component:
GO:0005689 U12-type spliceosomal complex


-  Descriptions from all associated GenBank mRNAs
  LF385357 - JP 2014500723-A/192860: Polycomb-Associated Non-Coding RNAs.
MA620934 - JP 2018138019-A/192860: Polycomb-Associated Non-Coding RNAs.
AK001878 - Homo sapiens cDNA FLJ11016 fis, clone PLACE1003334.
BC006986 - Homo sapiens RNA binding motif protein 41, mRNA (cDNA clone MGC:12215 IMAGE:3995903), complete cds.
AK023732 - Homo sapiens cDNA FLJ13670 fis, clone PLACE1011725.
AL832966 - Homo sapiens mRNA; cDNA DKFZp666B152 (from clone DKFZp666B152).
JD401905 - Sequence 382929 from Patent EP1572962.
JD425290 - Sequence 406314 from Patent EP1572962.
JD240819 - Sequence 221843 from Patent EP1572962.
JD043129 - Sequence 24153 from Patent EP1572962.
JD425289 - Sequence 406313 from Patent EP1572962.
JD441396 - Sequence 422420 from Patent EP1572962.
JD425286 - Sequence 406310 from Patent EP1572962.
JD564358 - Sequence 545382 from Patent EP1572962.
JD043128 - Sequence 24152 from Patent EP1572962.
JD284123 - Sequence 265147 from Patent EP1572962.
JD286738 - Sequence 267762 from Patent EP1572962.
JD498274 - Sequence 479298 from Patent EP1572962.
JD225581 - Sequence 206605 from Patent EP1572962.
JD413313 - Sequence 394337 from Patent EP1572962.
JD198023 - Sequence 179047 from Patent EP1572962.
JD337475 - Sequence 318499 from Patent EP1572962.
JD246791 - Sequence 227815 from Patent EP1572962.
JD165789 - Sequence 146813 from Patent EP1572962.
JD361488 - Sequence 342512 from Patent EP1572962.
JD052194 - Sequence 33218 from Patent EP1572962.
JD326249 - Sequence 307273 from Patent EP1572962.
JD304461 - Sequence 285485 from Patent EP1572962.
JD354903 - Sequence 335927 from Patent EP1572962.
JD362648 - Sequence 343672 from Patent EP1572962.
JD110051 - Sequence 91075 from Patent EP1572962.
JD312782 - Sequence 293806 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000372487.1, ENST00000372487.2, ENST00000372487.3, ENST00000372487.4, NM_001394127, Q5JSN7, Q5JSN8, Q96IZ5, Q9H8F7, Q9NV04, RBM41_HUMAN, uc004emy.1, uc004emy.2, uc004emy.3
UCSC ID: ENST00000372487.5
RefSeq Accession: NM_001171080
Protein: Q96IZ5 (aka RBM41_HUMAN)
CCDS: CCDS14526.1, CCDS55472.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.