Human Gene KCNE5 (ENST00000372101.3) from GENCODE V44
Description: Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 5 (KCNE5), mRNA. (from RefSeq NM_012282) RefSeq Summary (NM_012282): This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016]. Gencode Transcript: ENST00000372101.3 Gencode Gene: ENSG00000176076.7 Transcript (Including UTRs) Position: hg38 chrX:109,623,700-109,625,172 Size: 1,473 Total Exon Count: 1 Strand: - Coding Region Position: hg38 chrX:109,624,592-109,625,020 Size: 429 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9UJ90
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0008016 regulation of heart contraction GO:0060048 cardiac muscle contraction GO:0060306 regulation of membrane repolarization GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization GO:0071435 potassium ion export GO:0071805 potassium ion transmembrane transport GO:0086005 ventricular cardiac muscle cell action potential GO:0086013 membrane repolarization during cardiac muscle cell action potential GO:0086014 atrial cardiac muscle cell action potential GO:0086091 regulation of heart rate by cardiac conduction GO:1901379 regulation of potassium ion transmembrane transport GO:1901380 negative regulation of potassium ion transmembrane transport GO:1901381 positive regulation of potassium ion transmembrane transport GO:2001257 regulation of cation channel activity