Human Gene SLC25A5 (ENST00000317881.9) from GENCODE V44
  Description: Homo sapiens solute carrier family 25 member 5 (SLC25A5), mRNA. (from RefSeq NM_001152)
RefSeq Summary (NM_001152): This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013].
Gencode Transcript: ENST00000317881.9
Gencode Gene: ENSG00000005022.6
Transcript (Including UTRs)
   Position: hg38 chrX:119,468,444-119,471,396 Size: 2,953 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chrX:119,468,516-119,471,058 Size: 2,543 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:119,468,444-119,471,396)mRNA (may differ from genome)Protein (298 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ADT2_HUMAN
DESCRIPTION: RecName: Full=ADP/ATP translocase 2; AltName: Full=ADP,ATP carrier protein 2; AltName: Full=ADP,ATP carrier protein, fibroblast isoform; AltName: Full=Adenine nucleotide translocator 2; Short=ANT 2; AltName: Full=Solute carrier family 25 member 5;
FUNCTION: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
SUBUNIT: Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr.
INTERACTION: Q9Y6E7:SIRT4; NbExp=2; IntAct=EBI-355133, EBI-2606540;
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
MISCELLANEOUS: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SLC25A5
Diseases sorted by gene-association score: non-syndromic intellectual disability (9), male reproductive organ benign neoplasm (9), oxyphilic adenoma (8), prostatic adenoma (6), dilated cardiomyopathy (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 321.50 RPKM in Colon - Transverse
Total median expression: 6046.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.0072-0.278 Picture PostScript Text
3' UTR -67.80338-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002113 - Aden_trnslctor
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

ModBase Predicted Comparative 3D Structure on P05141
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005471 ATP:ADP antiporter activity
GO:0005515 protein binding
GO:0015207 adenine transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0031625 ubiquitin protein ligase binding

Biological Process:
GO:0007059 chromosome segregation
GO:0008284 positive regulation of cell proliferation
GO:0015853 adenine transport
GO:0015866 ADP transport
GO:0015867 ATP transport
GO:0016032 viral process
GO:0050796 regulation of insulin secretion
GO:0055085 transmembrane transport
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component:
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042645 mitochondrial nucleoid
GO:0043209 myelin sheath
GO:0045121 membrane raft
GO:0071817 MMXD complex


-  Descriptions from all associated GenBank mRNAs
  AK315292 - Homo sapiens cDNA, FLJ96310, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (SLC25A5), mRNA.
BC068199 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5, mRNA (cDNA clone IMAGE:4132690), partial cds.
BC056160 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5, mRNA (cDNA clone MGC:65136 IMAGE:3867331), complete cds.
JD461639 - Sequence 442663 from Patent EP1572962.
J02683 - Human ADP/ATP carrier protein mRNA, complete cds.
JD457712 - Sequence 438736 from Patent EP1572962.
JD226638 - Sequence 207662 from Patent EP1572962.
JD134705 - Sequence 115729 from Patent EP1572962.
DQ594014 - Homo sapiens piRNA piR-60126, complete sequence.
DQ571887 - Homo sapiens piRNA piR-31999, complete sequence.
LF211224 - JP 2014500723-A/18727: Polycomb-Associated Non-Coding RNAs.
MA446801 - JP 2018138019-A/18727: Polycomb-Associated Non-Coding RNAs.
CU691128 - Synthetic construct Homo sapiens gateway clone IMAGE:100021648 5' read SLC25A5 mRNA.
HQ448108 - Synthetic construct Homo sapiens clone IMAGE:100071488; CCSB011947_01 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (SLC25A5) gene, encodes complete protein.
KJ896424 - Synthetic construct Homo sapiens clone ccsbBroadEn_05818 SLC25A5 gene, encodes complete protein.
J03591 - Human ADP/ATP translocase mRNA, 3' end, clone pHAT3.
LF344719 - JP 2014500723-A/152222: Polycomb-Associated Non-Coding RNAs.
MA580296 - JP 2018138019-A/152222: Polycomb-Associated Non-Coding RNAs.
JA785059 - Sequence 21 from Patent WO2012069613.
DQ596923 - Homo sapiens piRNA piR-34989, complete sequence.
LF344717 - JP 2014500723-A/152220: Polycomb-Associated Non-Coding RNAs.
MA580294 - JP 2018138019-A/152220: Polycomb-Associated Non-Coding RNAs.
JD026762 - Sequence 7786 from Patent EP1572962.
JD035052 - Sequence 16076 from Patent EP1572962.
LF344715 - JP 2014500723-A/152218: Polycomb-Associated Non-Coding RNAs.
MA580292 - JP 2018138019-A/152218: Polycomb-Associated Non-Coding RNAs.
JD025105 - Sequence 6129 from Patent EP1572962.
LF344714 - JP 2014500723-A/152217: Polycomb-Associated Non-Coding RNAs.
MA580291 - JP 2018138019-A/152217: Polycomb-Associated Non-Coding RNAs.
JD188307 - Sequence 169331 from Patent EP1572962.
JD325227 - Sequence 306251 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

Reactome (by CSHL, EBI, and GO)

Protein P05141 (Reactome details) participates in the following event(s):

R-HSA-180905 Association of Vpr with ANT1
R-HSA-163215 SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane
R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-422356 Regulation of insulin secretion
R-HSA-162909 Host Interactions of HIV factors
R-HSA-163685 Energy Metabolism
R-HSA-162906 HIV Infection
R-HSA-1430728 Metabolism
R-HSA-5663205 Infectious disease
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: ADT2_HUMAN, ANT2, ENST00000317881.1, ENST00000317881.2, ENST00000317881.3, ENST00000317881.4, ENST00000317881.5, ENST00000317881.6, ENST00000317881.7, ENST00000317881.8, NM_001152, O43350, P05141, uc004erh.1, uc004erh.2, uc004erh.3, uc004erh.4, uc004erh.5, uc004erh.6
UCSC ID: ENST00000317881.9
RefSeq Accession: NM_001152
Protein: P05141 (aka ADT2_HUMAN)
CCDS: CCDS14578.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.