Human Gene ELF4 (ENST00000308167.10) from GENCODE V44
Description: Homo sapiens E74 like ETS transcription factor 4 (ELF4), transcript variant 1, mRNA. (from RefSeq NM_001421) RefSeq Summary (NM_001421): The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]. Gencode Transcript: ENST00000308167.10 Gencode Gene: ENSG00000102034.18 Transcript (Including UTRs) Position: hg38 chrX:130,063,955-130,110,497 Size: 46,543 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chrX:130,066,721-130,081,330 Size: 14,610 Coding Exon Count: 8
ID:ELF4_HUMAN DESCRIPTION: RecName: Full=ETS-related transcription factor Elf-4; AltName: Full=E74-like factor 4; AltName: Full=Myeloid Elf-1-like factor; FUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. SUBUNIT: Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C- terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ. SUBCELLULAR LOCATION: Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML. TISSUE SPECIFICITY: Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain. INDUCTION: By ponisterone A in erythroleukemia cells. DISEASE: Note=A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG. SIMILARITY: Belongs to the ETS family. SIMILARITY: Contains 1 ETS DNA-binding domain. SEQUENCE CAUTION: Sequence=AAC17452.1; Type=Frameshift; Positions=334, 412;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF12310 - Transcription factor protein N terminal PF00178 - Ets-domain
ModBase Predicted Comparative 3D Structure on Q99607
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001787 natural killer cell proliferation GO:0001866 NK T cell proliferation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0030154 cell differentiation GO:0045087 innate immune response GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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